Claims for Patent: 6,905,845

Summary for Patent: 6,905,845

Title:	House dust mite allergen, Der f VII, and uses therefor
Abstract:	Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acid of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleotide acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.
Inventor(s):	Thomas; Wayne Robert (Nedlands, AU), Chua; Kaw-Yan (Taipei, TW)
Assignee:	Heska Corporation (Fort Collins, CO)
Application Number:	10/024,955
Patent Claims:	1. An isolated nucleic acid sequence encoding a Dermatophagoides farinae VII (Der f VII) protein allergen wherein the nucleic acid comprises the nucleotide sequence as set forth in SEQ ID NO:6 or nucleotide bases 48 through 681 of the nucleotide sequence as set forth in SEQ ID NO: 6. 2. An isolated nucleic acid sequence encoding a Der f VII protein allergen, comprising the amino acid sequence shown in FIG. 6A and 6B (SEQ ID NO: 7), or the mature portion thereof. 3. A vector comprising the nucleic acid of claim 2. 4. A host cell containing the vector of claim 3. 5. A method of producing a Der f VII protein allergen comprising culturing the host cell of claim 4 under conditions appropriate for expression of Der f VII protein and isolating Der f VII protein from the culture.

Details for Patent 6,905,845

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides farinae	Injection	101834	09/15/1958		2013-03-12