Claims for Patent: 6,872,727

Summary for Patent: 6,872,727

Title:	Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation
Abstract:	Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.
Inventor(s):	Herrmann; Konrad (Leipzig, DE), Leistner; Siegfried (Leipzig, DE), Wippich; Petra (Hamburg, DE)
Assignee:	Privates Institut fur Biomedizinische Forschung und Beratung (Leipzig, DE)
Application Number:	09/830,518
Patent Claims:	1. A method of inhibiting collagenase/MMP activities in a mammal comprising administering to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions with the general structures Ia and Ib, ##STR34## where: R.sup.1 is hydrogen, methyl, or ethyl; R.sup.2 is hydrogen or methyl; R.sup.3 is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); Alk is C.sub.1 -C.sub.5 branched or unbranched alkyl; R.sup.4 is hydrogen, benzyl, or phenyl; n is 0, 1 or 2; Alk* is C.sub.2 -C.sub.12 branched or unbranched alkylene, with the exception of 3-methylpropylene [--CH.sub.2 --CH.sub.2 --CH(CH.sub.3)-]; X is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene ring, R.sup.5 is hydrogen, 6-methyl, 8-methyl, 6-fluoro, 6-choloro, 6-bromo, 6-methylthio, or 6,7-dimethoxy, as well as the tautomers and pharmacologically relevant salts of these compounds. 2. A method of inhibiting tumor metastasis and invasion in a mammal comprising administering to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions with the general structures Ia and Ib, ##STR35## where: R.sup.1 is hydrogen, methyl, or ethyl; R.sup.2 is hydrogen or methyl; R.sup.3 is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); Alk is C.sub.1 -C.sub.5 branched or unbranched alkyl; R.sup.4 is hydrogen, benzyl, or phenyl; n is 0, 1 or 2; Alk* is C.sub.2 -C.sub.12 branched or unbranched alkylene, with the exception of 3-methylpropylene [--CH.sub.2 --CH.sub.2 --CH(CH.sub.3)--], X is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene ring, R.sup.5 is hydrogen, 6-methyl, 8-methyl, 6-fluoro, 6-choloro, 6-bromo, 6-methylthio, or 6,7-dimethoxy, as well as the tautomers and pharmacologically relevant salts of these compounds. 3. A method of treating UV-induced erythema in a mammal comprising administering to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions with the general structures Ia and Ib, ##STR36## where: R.sup.1 is hydrogen, methyl, or ethyl; R.sup.2 is hydrogen or methyl; R.sup.3 is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); Alk is C.sub.1 -C.sub.5 branched or unbranched alkyl; R.sup.4 is hydrogen, benzyl, or phenyl; n is 0, 1 or 2; Alk* is C.sub.2 -C.sub.12 branched or unbranched alkylene, with the exception of 3-methylpropylene [--CH.sub.2 --CH.sub.2 --CH(CH.sub.3)--]; X is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene ring, R.sup.5 is hydrogen, 6-methyl, 8-methyl, 6-fluoro, 6-choloro, 6-bromo, 6-methylthio, or 6,7-dimethoxy, as well as the tautomers and pharmacologically relevant salts of these compounds. 4. A method of treating rheumatic diseases in a mammal comprising administration to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions of the general structures Ia and Ib, ##STR37## where: R.sup.1 is hydrogen, methyl, or ethyl; R.sup.2 is hydrogen or methyl; R.sup.3 is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); Alk is C.sub.1 -C.sub.5 branched or unbranched alkyl; R.sup.4 is hydrogen, benzyl, or phenyl; n is 0, 1 or 2; Alk* is C.sub.2 -C.sub.12 branched or unbranched alkylene, with the exception of 3-methylpropylene [--CH.sub.2 --CH.sub.2 --CH(CH.sub.3)--]; X is mercapto or hydroxyaminoacylalkylthio (--SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene rine, R.sup.5 is hydrogen, 6-methyl, 8-methyl, 6-fluoro, 6-choloro, 6-bromo, 6-methylthio, or 6,7-dimethoxy, as well as the tautomers and pharmacologically relevant salts of these compounds. 5. The method of claim 1, wherein the one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) are compounds of the general structures IIa and IIb ##STR38## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Alk, Alk*, n, and X are defined as in claim 1, including their tautomers and pharmacologically relevant salts. 6. The method of claim 2, wherein the one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) are compounds of the general structures IIa and IIb ##STR39## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Alk, Alk*, n, and X are defined as in claim 2, including their tautomers and pharmacologically relevant salts. 7. The method of claim 3, wherein the one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) are compounds of the general structures IIa and IIb ##STR40## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Alk, Alk*, n, and X are defined as in claim 3, including their tautomers and pharmacologically relevant salts. 8. The method of claim 4, wherein the one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) are compounds of the general structures IIa and IIb ##STR41## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Alk, Alk*, n, and X are defined as in claim 4, including their tautomers and pharmacologically relevant salts.

Details for Patent 6,872,727

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2019-08-26