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Last Updated: March 28, 2024

Claims for Patent: 6,814,966


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Summary for Patent: 6,814,966
Title: Methods for treating glaucoma
Abstract:This invention provides a method for treating a subject with glaucoma comprising the steps of administrating a compound or composition which antagonize, inhibits, inactivates, reduce, suppresses, antagonizes, and/or limits the release, synthesis, or production from cells of TNF-.alpha. thereby treating the subject with glaucoma.
Inventor(s): Wax; Martin B. (Wildwood, MO), Tezel; Gulgun (Louisville, KY)
Assignee: Pharmacia Corporation (St. Louis, MO)
Application Number:09/591,561
Patent Claims:1. A method for treating a subject with glaucoma comprising the steps of administrating a compound or composition containing an agent, which antagonize, inhibits, inactivates, reduce, suppresses, antagonizes, and/or limits the release, synthesis, or production from cells of TNF-.alpha. thereby treating the subject with glaucoma.

2. The method of claim 1, wherein the compound or composition suppresses the level or production of TNF-.alpha..

3. The method of claim 1, wherein the compound or composition inactivates circulating TNF-.alpha..

4. The method of claim 1, wherein the molecule is anti-TNF-.alpha. antibody.

5. The method of claim 4, wherein the molecule is a monoclonal or polyclonal antibody.

6. The method of claim 5, wherein the molecule is infliximab.

7. A pharmaceutical composition of claim 1 and a diluent and suitable carrier.

8. The method of claim 1, wherein the compound or composition is administered ocularly, parenterally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, intravascularly, or subcutaneously, intraperitonealytopical drops or ointment, periocular injection, systemically by intravenous injection or orally, intracamerally into the anterior chamber or vitreous, via a depot attached to the intraocular lens implant inserted during surgery, or via a depot placed in the eye sutured in the anterior chamber or vitreous.

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