Claims for Patent: 6,812,214

Summary for Patent: 6,812,214

Title:	Use of harpagid-related compounds for prevention and treatment of osteoporosis, arthritis and ruptured disc and pharmaceutical composition containing the same
Abstract:	In the present invention, it is discovered that a compound of formula (I) has a potent effect for treatment of osteoporosis, arthritis and ruptured disc: ##STR1## in which R.sub.1 represents hydrogen atom or alkyl group and R.sub.2 represents hydrogen atom r cinnamoyl group. Therefore, the compound of formula (I) can be used for prevention and treatment of osteoporosis, arthritis and ruptured disc. Thus, the present invention provides a pharmaceutical preparation containing as an effective component a compound of formula (I) in combination with a pharmaceutically acceptable auxiliary, diluent, isotonic agent, preservative, lubricant and solubilizing aid, which is formulated in the form of a pharmaceutically acceptable preparation and has a potent effect for osteoporosis, arthritis and ruptured disc.
Inventor(s):	Shin; Joon Shik (635, Shinsa-dong, Kangnam-ku, Seoul, KR), Kim; Sang Tae (Seoul, KR), Han; Yong Nam (Seoul, KR)
Assignee:	Shin; Joon Shik (Seoul, KR)
Application Number:	09/995,691
Patent Claims:	1. A method of treating arthritis, osteoporosis and ruptured disc comprising administering to a patient in need thereof a pharmaceutically acceptable amount of the compound of formula (I): ##STR3## in which R1 represents a hydrogen atom or an alkyl group; and R2 represents a hydrogen atom; and Glc represents glucose; along with a pharmaceutically acceptable adjuvant. 2. A pharmaceutical preparation containing as an effective component a compound represented by the following formula (I): ##STR4## in which R.sub.1 represents a hydrogen atom or an alkyl group and R.sub.2 represents a hydrogen atom, and Glc represents glucose wherein the pharmaceutical preparation has a potent effect against osteoporosis, arthritis and ruptured disc and the compound represented by formula (1) is present in a concentration amount of from 2.5 to 5 mg compound per ml composition. 3. A pharmaceutical preparation containing as an effective component a compound represented by the following formula (I): ##STR5## in which R.sub.1 represents a hydrogen atom or an alkyl group and R.sub.2 represents a hydrogen atom, and Glc represents glucose and one or more materials selected from the group consisting of allendrate, tamoxifen, vitamin D.sub.3, parathyroid hormone (PTH), sulfasalazine, thioredoxin reductase, alendronate, raloxifene, calcitonin, estradiol, genistein, 1,25-dihydroxyvitamin D.sub.3, biphosphonates, shinbarometin and shinbarometin acetate wherein said pharmaceutical preparation has a potent effect against osteoporosis, arthritis and ruptured disc.

Details for Patent 6,812,214

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2020-11-29