Claims for Patent: 6,800,290

Summary for Patent: 6,800,290

Title:	Variants of allergenic proteins of the group 2 of dermatophagoides
Abstract:	Variants of allergens of Dermatophagoides pteronyssinus species with reduced allergenic activity.
Inventor(s):	Sturaro; Monica (Rome, IT), Viotti; Angelo (Rome, IT), Falagiani; Paolo (Milan, IT), Mistrello; Giovanni (Milan, IT), Roncarolo; Daniela (Milan, IT), Zanotta; Stefania (Rome, IT)
Assignee:	Consiglio Nazionale Delle Ricerche (Rome, IT)
Application Number:	09/949,889
Patent Claims:	1. A variant of a Der p 2 allergen, comprising a mature Der p 2 protein exhibiting at least 85% sequence identity to amino acids 17-145 of SEQ ID No. 3, wherein at least four of the Lys residues present at positions 33, 48, 82, 96, 100, and 126 of Der p 2 are substituted with neutral or polar amino acids, and wherein said variant exhibits reduced IgE reactivity in serum from patients allergic to Dermatophagoides pteronyssinus mites as compared to natural Der p 2 allergen. 2. A pharmaceutical composition, comprising: a variant of a Der p 2 allergen according to claim 1, together with pharmaceutically acceptable excipients. 3. The variant according to claim 1, wherein said residues are substituted with alanine. 4. A variant of the natural form of Der p 2, comprising SEQ ID No. 4. 5. The variant according to claim 4, consisting of SEQ ID No. 4. 6. A pharmaceutical composition, comprising a variant according to claim 4, together with pharmaceutically acceptable excipients.

Details for Patent 6,800,290

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides pteronyssinus	Injection	101835	09/15/1958		2020-09-12