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Last Updated: October 21, 2019

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Claims for Patent: 6,787,518

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Summary for Patent: 6,787,518
Title: Therapeutics of osteoarthritis and inflammatory joint disease
Abstract:Drugs for preventing or treating diseases that involve the destruction and degeneration of articular cartilage tissue contain a parathyroid hormone related peptide (PTHrP) or a PTHrP derived substance as an effective ingredient.
Inventor(s): Kato; Yukio (Hiroshima-shi, Hiroshima-ken, JP), Iwamoto; Masahiro (Minoo-shi, Osaka 562, JP), Koike; Tatsuya (Shijonawate-shi, Osaka 575, JP)
Assignee:
Application Number:08/894,443
Patent Claims:1. A method for suppressing the incorporation of calcium into chondrocytes or the calcification of cartilage and subchondral bone, comprising administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.

2. The method according to claim 1, wherein said disease that involves the destruction and degeneration of articular cartilage tissue is osteoarthritis.

3. A method for suppressing the formation of type X collagen in cartilage, subchondral bone or chondrocytes, comprising administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.

4. The method according to claim 3, wherein said disease that involves the destruction and degeneration of articular cartilage tissue is osteoarthritis.

5. A method for suppressing the alkali phosphatase activity in cartilage, subchondral bone or chondrocytes, comprising administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.

6. The method according to claim 5, wherein said disease that involves the destruction and degeneration of articular cartilage tissue is osteoarthritis.

Summary for Patent:   Start Trial

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan7-030803Feb 20, 1995
PCT Information
PCT FiledFebruary 19, 1996PCT Application Number:PCT/JP96/00362
PCT Publication Date:August 29, 1996PCT Publication Number:WO96/25944

Details for Patent 6,787,518

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial 2015-02-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial 2015-02-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial 2015-02-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial 2015-02-20 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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