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Last Updated: March 28, 2024

Claims for Patent: 6,762,295


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Summary for Patent: 6,762,295
Title: Protective helicobacter antigens
Abstract:Protective Helicobacter antigens, especially H. pylori antigens, and the use of these antigens for the treatment of or prevention of, gastroduodenal disease associated with H. pylori infection.
Inventor(s): Doidge; Christopher Vincent (Box Hill, AU), Lee; Adrian (Lane Cove, AU), Radcliff; Fiona Jane (Sydney, AU), Hocking; Dianna Margaret (Flemington, AU), Webb; Elizabeth Ann (Eltham, AU)
Assignee: CSL Limited (Parkville, AU) The University of New South Wales (Kensington, AU)
Application Number:08/945,038
Patent Claims:1. An isolated nucleic acid molecule which encodes a Helicobacter antigen having a molecular mass of approximately 36 kDa, said nucleic acid molecule consisting essentially of the sequence of nucleotides of SEQ ID NO:3.

2. A recombinant DNA molecule comprising an expression control sequence operatively linked to the nucleic acid molecule according to claim 1.

3. The recombinant DNA molecule according to claim 2, wherein said expression control sequence comprises a promoter sequence and an initiator sequence, and said sequence of nucleotides is located 3' to the promoter and initiator sequences.

4. A recombinant DNA cloning vector comprising the recombinant DNA molecule according to claim 2.

5. The recombinant DNA cloning vector according to claim 4, wherein said vector is a plasmid.

6. The host cell transfected or transformed with the recombinant DNA molecule according to claim 1.

7. A host cell according to claim 6, wherein said host cell is E. coli.

8. A preparation for use in the treatment or prevention of Helicobacter infection in a mammalian host, which comprises a vector which is a host cell capable of expressing a Heilcobacter antigen having a molecular mass of approximately 36 kDa, wherein said host cell comprises a heterologous nucleic acid molecule consisting essentially of the sequence of nucleotides which encodes SEQ ID NO:4.

9. A preparation according 8, wherein said vector is a bacterium that colonizes the gastrointestinal tract of the mammalian host.

10. A preparation according to claim 8, wherein said vector is a bacterium selected from the group of Salmonella, Shigella, Yersinia, Vibrio, Escherichia and Bacillus Calmette-Guerin (BCG).

11. An isolated nucleic acid molecule which encodes a Helicobacter antigen having a molecular mass of approximately 36 kDa, said nucleic acid molecule consisting essentially of the sequence of nucleotides which encodes SEQ ID NO:4.

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