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Last Updated: March 29, 2024

Claims for Patent: 6,761,856


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Summary for Patent: 6,761,856
Title: Apparatus for determining platelet inhibitor response
Abstract:An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets, the apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.
Inventor(s): Baugh; Robert F. (Parker, CO), Lane; Carole G. (Greenwood Village, CO), Wilson; Adrian C. (Denver, CO)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Application Number:10/410,003
Patent Claims:1. An apparatus for performing an activated clotting time test on a sample of blood, said apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.

2. The apparatus of claim 1, wherein the anticoagulant is heparin.

3. The apparatus of claim 2, wherein the amount of heparin in said cell is between about 1 unit and about 4 units per milliliter of blood sample.

4. The apparatus of claim 1, wherein the clotting activator is a particle having a negatively charged surface.

5. The apparatus of claim 3, wherein said particle is kaolin.

6. The apparatus of claim 4, wherein the amount of contact activator in said cell is between about 2 percent and about 15 percent.

7. The apparatus of claim 4, wherein said particle is diatomaceous earth.

8. The apparatus of claim 4, wherein said particle is powdered glass.

9. The apparatus of claim 4, wherein said particle is silica.

10. The apparatus of claim 1, wherein said platelet inactivating agent is selected from the group consisting of Abciximab, 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid, hydrochloride trihydrate, and acetylsalicylic acid.

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