Claims for Patent: 6,746,485

Summary for Patent: 6,746,485

Title:	Hair used as a biologic disk, replacement, and/or structure and method
Abstract:	Hair is used as a biologic disk, replacement, and/or structure.
Inventor(s):	Zucherman; James F. (San Francisco, CA), Hsu; Ken Y. (San Francisco, CA)
Assignee:	St. Francis Medical Technologies, Inc. (Alameda, CA)
Application Number:	09/504,826
Patent Claims:	1. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack with keratin sulfate placed in the sack. 2. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack with a hydrophilic gel placed in the sack. 3. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack with the sack at least partially surrounding at least one of a hydrogel, a hydrophilic gel, keratin sulfate, and a growth factor. 4. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack with the sack at least partially surrounding a cartilage growth factor. 5. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack with at least some of which has been processed as keratin sulfate. 6. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein a cartilage growth factor is applied to said hair. 7. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein BMP is applied to said hair. 8. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein one or more morphogenetic growth factors is applied to said hair. 9. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein one or more recombinant growth factors is applied to said hair. 10. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; wherein an outer surface of the sack is covered with a polymer material; and wherein said polymer material can include at least one of the group consisting of polypropylene, polylactic acid materials, polyesther polymer mesh, composites of collagen and BMP, titanium fiber with BMP with or without non-collagenase proteins, polydioxanone, polyphosphazenes and BMP, ceramic collagen composite, expanded polytetrafluoroethylene barrier membranes, and ethylene-vinyl acetate copolymers in methylene chloride (Elvax 40). 11. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein said hair is treated with at least one of the group consisting of: heparin, dextran, protease, elastase, collagenase, guanidine hydrochloride, and lithium bromide. 12. A replacement for at least part of a vertebral disk, the replacement comprising hair; and wherein the replacement is comprised of said hair formed into a sack; and wherein said sack is filled with a material which has a state dependent upon the temperature of the material. 13. The replacement of claim 12 comprised of human hair. 14. The replacement of claim 12 comprised of woven hair. 15. The replacement of claim 12 comprised of matted hair. 16. The replacement of claim 12 wherein said hair is formed into a replacement annulus. 17. The replacement of claim 12 wherein said hair is used to construct in a replacement annulus. 18. The replacement of claim 12 wherein said hair is one of autologous hair and homologous hair. 19. The replacement of claim 12 wherein said hair is one of autogeneic hair and allogeneic hair. 20. The replacement of claim 12 wherein said sack at least partially surrounds a cartilage growth factor. 21. The replacement of claim 12 wherein said sack surrounds hair treated to model a natural disk. 22. The replacement of claim 12 wherein the replacement is comprised of at least two layers of said hair. 23. The replacement of claim 12 wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair. 24. The replacement of claim 23 wherein the hair in the first layer has a different orientation than the hair in the second layer. 25. The replacement of claim 12 wherein a cartilage growth factor is applied to said hair. 26. The replacement of claim 12 wherein BMP is applied to said hair. 27. The replacement of claim 12 wherein one or more morphogenetic growth factors is applied to said hair. 28. The replacement of claim 12 wherein one or more recombinant growth factors is applied to said hair. 29. The replacement of claim 12 wherein outer surface of the sack is covered with a polymer material. 30. The replacement of claim 29 wherein said polymer material can include at least one of the group consisting of polypropylene, polylactic acid materials, polyesther polymer mesh, composites of collagen and BMP, titanium fiber with BMP with or without non-collagenase proteins, polydioxanone, polyphosphazenes and BMP, ceramic collagen composite, expanded polytetrafluoroethylene barrier membranes, and ethylene-vinyl acetate copolymers in methylene chloride (Elvax 40). 31. The replacement of claim 12 wherein said hair is treated with at least one of the group consisting of: heparin, dextran, protease, elastase, collagenase, guanidine hydrochloride, and lithium bromide. 32. The replacement of claim 12 wherein said hair is woven and/or blended together using at least one of the following techniques consisting of: matting, denaturation, acid treatment, and weaving. 33. The replacement of claim 12 wherein said hair is treated with one or more bone growth factors. 34. The replacement of claim 12 comprised of hair at least some of which has been processed as keratin sulfate. 35. The replacement of claim 12 wherein said sack contains one or more bone growth factor materials. 36. A replacement for at least part of a vertebral disk, the replacement comprising hair; and wherein the replacement is comprised of said hair formed into a sack; and wherein said sack is filled with a material; and wherein said material becomes at least one of more viscous and resilient when the material reaches the temperature of a patient's body. 37. The replacement of claim 36 comprised of human hair. 38. The replacement of claim 36 comprised of woven hair. 39. The replacement of claim 36 comprised of matted hair. 40. The replacement of claim 36 wherein said hair is formed into a replacement annulus. 41. The replacement of claim 36 wherein said hair is used to construct in a replacement annulus. 42. The replacement of claim 36 wherein said hair is one of autologous hair and homologous hair. 43. The replacement of claim 36 wherein said hair is one of autogeneic hair and allogeneic hair. 44. The replacement of claim 36 wherein said sack at least partially surrounds a cartilage growth factor. 45. The replacement of claim 36 comprised of hair in the center of the sack treated to model a natural disk. 46. The replacement of claim 36 wherein the sack is comprised of at least two layers of said hair. 47. The replacement of claim 36 wherein the sack is comprised of at least a first layer of woven hair and a second layer of woven hair. 48. The replacement of claim 47 wherein the hair in the first layer has a different orientation than the hair in the second layer. 49. The replacement of claim 36 wherein a cartilage growth factor is applied to said hair. 50. The replacement of claim 36 wherein BMP is applied to said hair. 51. The replacement of claim 36 wherein one or more morphogenetic growth factors is applied to said hair. 52. The replacement of claim 36 wherein one or more recombinant growth factors is applied to said hair. 53. The replacement of claim 36 wherein an outer surface of the sack is covered with a polymer material. 54. The replacement of claim 53 wherein said polymer material can include at least one of the group consisting of polypropylene, polylactic acid materials, polyesther polymer mesh, composites of collagen and BMP, titanium fiber with BMP with or without non-collagenase proteins, polydioxanone, polyphosphazenes and BMP, ceramic collagen composite, expanded polytetrafluoroethylene barrier membranes, and ethylene-vinyl acetate copolymers in methylene chloride (Elvax 40). 55. The replacement of claim 36 wherein said hair is treated with at least one of the group consisting of: heparin, dextran, protease, elastase, collagenase, guanidine hydrochloride, and lithium bromide. 56. The replacement of claim 36 wherein said hair is woven and/or blended together using at least one of the following techniques consisting of: matting, denaturation, acid treatment, and weaving. 57. The replacement of claim 36 wherein said hair is treated with one or more bone growth factors. 58. The replacement of claim 36 comprised of hair at least some of which has been processed as keratin sulfate. 59. The replacement of claim 36 wherein said sack contains one or more bone growth factor materials. 60. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein said hair is treated with one or more bone growth factors. 61. A replacement for at least part of a vertebral disk, the replacement comprising hair formed into a sack; and wherein said sack is filled with one or more bone growth factor materials. 62. A method of delivering a disk prosthetic device to an intervertebral space comprising the steps of: first delivering a disk prosthetic device comprised in part of hair to the intervertebral space said disk prosthetic device formed into a sack; and second delivering a filling material to the disk prosthetic device. 63. A replacement for at least part of a vertebral disk, the replacement comprising hair; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein the hair formed into a sack with keratin sulfate placed in the sack. 64. A replacement for at least part of a vertebral disk, the replacement comprising hair; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein the hair is formed into a sack with a hydrophillic gel placed in the sack. 65. A replacement for at least part of a vertebral disk, the replacement comprising hair; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein said hair in the first layer has a different orientation than said hair in the second layer; and wherein said hair is formed into a structure with the structure at least partially surrounding a cartilage growth factor. 66. A replacement for at least part of a vertebral disk, the replacement comprising hair; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein the hair at least some of which has been processed at keratin sulfate. 67. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein a cartilage growth factor is applied to said hair. 68. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein BMP is applied to said hair. 69. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein one or more morphogenetic growth factors is applied to said hair. 70. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein one or more recombinant growth factors is applied to said hair. 71. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein said hair is formed into a sack and the outer surface of the sack is covered with a polymer material. 72. The replacement of claim 71 wherein said polymer material can include at least one of the group consisting of polypropylene, polylactic acid materials, polyesther polymer mesh, composites of collagen and BMP, titanium fiber with BMP with or without non-collagenase proteins, polydioxanone, polyphosphazenes and BMP, ceramic collagen composite, expanded polytetrafluoroethylene barrier membranes, and ethylene-vinyl acetate copolymers in methylene chloride (Elvax 40). 73. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein said hair is treated with at least one of the group consisting of: heparin, dextran, protease, elastase, collagenase, guanidine hydrochloride, and lithium bromide. 74. A replacement for at least part of a vertebral disk; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein said hair is treated with one or more bone growth factors. 75. A replacement for at least part of a vertebral disk, the replacement comprised of hair formed in to a sack; wherein the replacement is comprised of at least a first layer of woven hair and a second layer of woven hair; wherein the hair in the first layer has a different orientation than the hair in the second layer; and wherein said sack is filled with one or more bone growth factor materials.

Details for Patent 6,746,485

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2019-02-18