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Last Updated: March 29, 2024

Claims for Patent: 6,652,854


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Summary for Patent: 6,652,854
Title: Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
Abstract:The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNF.alpha. inhibitors by administering agents that inhibit signal transduction by CD30 or IL-1. Included also are treatments involving concurrently administering agents that block the CD30/CD30L interaction and agents that antagonize the IL-4/IL-4R interaction. Additionally provided is an animal model for screening candidate agents for their efficacy in treating conditions that are resistant to treatment with TNF.alpha. inhibitors.
Inventor(s): Mohler; Kendall M. (Poulsbo, WA), Barone; Dauphine S. (Everett, WA), Kennedy; Mary K. (Seattle, WA)
Assignee: Immunex Corporation (Seattle, WA)
Application Number:09/921,667
Patent Claims:1. A method of treating multiple sclerosis, rheumatoid arthritis or systemic lupus erythematosous in a patient, said method comprising administering to the patient an agent that comprises an antibody that is specific for CD30L, wherein the agent is administered according to a regimen of dose and frequency of administration that is adequate to induce a sustained improvement in at least one indicator that reflects the severity of the patient's condition, the improvement being considered sustained if the patient exhibits the improvement on at least two occasions separated by at least one day.

2. A method according to claim 1, wherein the patient is a human.

3. A method according to claim 2, wherein the condition is rheumatoid arthritis.

4. A method according to claim 1, wherein the agent is administered concurrently with a second agent that is an antagonist of TNF.alpha., and further wherein the patient's condition is selected from the group consisting of rheumatoid arthritis and systemic lupus erythematosous.

5. A method according to claim 2, wherein the patient's condition is multiple sclerosis.

6. A method according to claim 2, wherein the patient's condition is systemic lupus erythematosus.

7. A method according to claim 1, wherein the antibody specific for CD30L is a monoclonal antibody.

8. A method according to claim 1, wherein the antibody specific for CD30L is a humanized antibody.

9. A method according to claim 1, wherein the antibody specific for CD30L is a human antibody.

10. A method according to claim 4, wherein the antagonist of TNF.alpha. is selected from the group consisting of etanercept, p55 TNFR-Ig fusion protein and an antibody against TNF.alpha..

11. A method according to claim 10, wherein the antagonist of TNF.alpha. is an antibody against TNF.alpha., and further wherein said antibody is selected from the group consisting of infliximab, D2E7 and CDP571.

12. A method according to claim 1, wherein said agent further comprises a physiologically acceptable carrier, excipient and/or diluent.

13. A method according to claim 4, wherein the antibody specific for CD30L is a monoclonal antibody.

14. A method according to claim 4, wherein the antibody specific for CD30L is a humanized antibody.

15. A method according to claim 4, wherein the antibody specific for CD30L is a human antibody.

16. A method according to claim 3, wherein the antibody specific for CD30L is a monoclonal antibody.

17. A method according to claim 3, wherein the antibody specific for CD30L is a humanized antibody.

18. A method according to claim 3, wherein the antibody specific for CD30L is a human antibody.

19. A method according to claim 5, wherein the antibody specific for CD30L is a monoclonal antibody.

20. A method according to claim 5, wherein the antibody specific for CD30L is a humanized antibody.

21. A method according to claim 5, wherein the antibody specific for CD30L is a human antibody.

22. A method according to claim 6, wherein the antibody specific for CD30L is a monoclonal antibody.

23. A method according to claim 6, wherein the antibody specific for CD30L is a humanized antibody.

24. A method according to claim 6, wherein the antibody specific for CD30L is a human antibody.

Details for Patent 6,652,854

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 ⤷  Try a Trial 2020-08-08
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2020-08-08
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2020-08-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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