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Last Updated: April 19, 2024

Claims for Patent: 6,635,247

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Summary for Patent: 6,635,247

Title:	Hypoparathyroid therapy
Abstract:	A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon parathyroid hormone secretion. A method for treating hyperparathyroidism and/or hypercalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates a parathyroid hormone secreting parathyroid cell, thereby reducing a stimulatory effect upon parathyroid hormone secretion.
Inventor(s):	Donovan; Stephen (Capistrano Beach, CA)
Assignee:	Allergan, Inc. (Irvine, CA)
Application Number:	09/835,949
Patent Claims:	1. A method for treating hypoparathyroidism, the method comprising the step of local administration in vivo to a parathyroid gland of a human patient of a therapeutically effective amount of a botulinum toxin_type A, B, C.sub.1, D, E, F or G, thereby increasing a deficient parathyroid hormone secretion from a parathyroid hormone secreting parathyroid cell and treating hypoparathyroidism. 2. The method of claim 1, wherein the botulinum toxin is botulinum toxin type A. 3. The method of claim 1, wherein the botulinum toxin is administered in an amount of between 10.sup.-3 units per kg of patient weight and 35 units per kg of patient weight. 4. A method for treating hypoparathyroidism, the method comprising the step of local administration in vivo to a parathyroid gland of a human patient of a therapeutically effective amount of a botulinum toxin type A, thereby increasing a deficient parathyroid hormone secretion from a parathyroid hormone secreting parathyroid cell and treating hypoparathyroidism.

Details for Patent 6,635,247

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2020-02-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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