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Last Updated: April 25, 2024

Claims for Patent: 6,582,711

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Summary for Patent: 6,582,711

Title:	Hydroalcoholic compositions thickened using polymers
Abstract:	An antimicrobial hydroalcoholic composition comprising hydroalcoholic solvent system comprising a lower alcohol and water in a weight ratio of at least about 50:50; a thickener system comprising at least one cationic or nonionic polymeric thickener that is solid at ambient temperature; and a secondary antimicrobial agent.
Inventor(s):	Asmus; Robert A. (Hudson, WI), Scholz; Matthew T. (Woodbury, MN)
Assignee:	3M Innovative Properties Company (St. Paul, MN)
Application Number:	08/781,095
Patent Claims:	1. An antimicrobial hydroalcoholic composition comprising: (a) a hydroalcoholic solvent system comprising a lower alcohol selected from the group consisting of ethanol, 2-propanol, n-propanol, and combinations thereof, and water in a weight ratio of lower alcohol to water of at least about 60:40; (b) a thickener system comprising at least one cationic polymeric thickener derived from ethylenically unsaturated monomers that is solid at ambient temperature; wherein the cationic thickener is selected such that the composition has a viscosity of at least about 10,000 centipoise at 23.degree. C.; wherein the thickener system is present in an amount of at least about 0.5% by weight, based on the total weight of the composition; and a secondary antimicrobial agent. 2. The composition of claim 1 which has a pH of at least about 5. 3. The composition of claim 1 wherein the secondary antimicrobial agent comprises a chlorhexidine salt in an amount of at least about 0.5% by weight, based on the total weight of the composition, and the composition has a viscosity of greater than about 60,000 cps at 23.degree. C. 4. The composition of claim 1 wherein the ethylenically unsaturated monomers are selected from the group of acrylates, acrylamides, vinyl lactams, vinyl acetates, methyl vinyl ethers, styrene, and acrylonitrile. 5. The composition of claim 1 wherein the thickener system further comprises at least one nonionic polymeric thickener. 6. The composition of claim 5 wherein the nonionic polymeric thickener is selected from the group consisting of modified celluloses, associative polymers derived from nonionic ethylenically unsaturated monomers wherein at least one comonomer has at least 16 carbon atoms, and polymers based on ethylenically unsaturated monomers selected from the group of acrylates, acrylamides, vinyl lactams, vinyl acetate and it hydrolyzed derivatives, methyl vinyl ethers, styrene, and acrylonitrile. 7. The composition of claim 1 wherein the cationic polymer is a synthetic poly(quaternary amine) polymer. 8. The composition of claim 1 wherein the thickener system is selected such that the composition has a viscosity of at least about 50,000 centipoise at 23.degree. C. 9. The composition of claim 1 wherein the thickener system is present in an amount of less than about 10% by weight, based on the total weight of the composition. 10. The composition of claim 1 wherein the thickener system is present in an amount of greater than about 2% by weight, based on the total weight of the composition. 11. The composition of claim 1 wherein the composition is substantially free of ions in excess of the cations and counterions associated with the cation polymer. 12. The composition of claim 1 wherein the polymer is at least partially crosslinked. 13. The composition of claim 12 wherein the partially crosslinked polymer comprises an N-vinyl lactam. 14. The composition of claim 1 wherein the secondary antimicrobial agent is selected from the group consisting of chlorhexidine salts, iodine, triclosan, PCMX, and mixtures thereof. 15. The composition of claim 1 wherein the cationic polymeric thickener is soluble. 16. The composition of claim 1 wherein the cationic polymeric thickener is swellable. 17. The composition of claim 1 wherein the cationic polymeric thickener is an associative polymeric thickener. 18. The composition of claim 17 wherein the associative polymeric thickener is derived from ethylenically unsaturated monomers wherein at least one comonomer has an alkyl side chain of at least 16 carbon atoms. 19. The composition of claim 1 further comprising at least one lipophilic emollient. 20. The composition of claim 1 wherein the lower alcohol is selected from the group consisting of ethanol, 2-propanol, n-propanol, and mixtures thereof. 21. The composition of claim 1 which is stable and does not separate more than about 10% by volume when centrifuged for 30 minutes at 1545.times.g. 22. The composition of claim 1 further comprising a pharmaceutical agent selected from the group consisting of steroidal antiinflammatory drugs; nonsteroidal antiinflammatory drugs; penicillins; cephalosporins; quinolones; antiprotazoals; antifungals; vasodilators; calcium channel blockers; bronchodilators; enzyme inhibitors; antihypertensives; leukotriene antagonists; antiulceratives; steroidal hormones; antivirals; immunomodulators; local anesthetics; cardiotonics; antitussives; antihistamines; narcotic analgesics; peptide hormones; cardioactive products; proteinaceous products; enzymes; antinauseants; anticonvulsants; immunosuppressives; psychotherapeutics; sedatives; anticoagulants; analgesics; antimigraine agents; antiarrhythmic agents; antemetics; anticancer agents; neurologic agents; hemostatics; antiobesity agents pharmaceutically acceptable salts and esters thereof; nicotine; and combinations thereof. 23. The composition of claim 1 wherein the ethylenically unsaturated monomers are selected from the group of acrylates and acrylamides. 24. The composition of claim 23 wherein the ethylenically unsaturated monomer further comprises a nonionic monomer selected from the group of acrylates, acrylamides, vinyl lactams, vinyl acetates, methyl vinyl ethers, styrene, and acrylonitrile. 25. The composition of claim 22 wherein the enzyme inhibitor is selected from the group consisting of collagenase inhibitors, protease inhibitors, elastase inhibitors, lipoxygenase inhibitors, and angiotensin converting enzyme inhibitors.

Details for Patent 6,582,711

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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