Claims for Patent: 6,576,233

Summary for Patent: 6,576,233

Title:	Dietary supplementation with, and methods for preparation of yeast-derived selenium salts
Abstract:	The present invention solves the need for non-toxic forms of selenium which is an essential part of the human diet. This invention provides novel dried-yeast products containing selenium as well as a method of producing the dried yeast products. The method uses selenium having high biological activity but low toxicity. The invention also provides nutritional supplements containing the novel selenium containing dried yeast products and methods of administering these products and supplements to improve human health. The invention also provides a practically non-toxic yeast selenium product having increased intracellular selenium concentrations and methods to reduce tumor cell growth by administration of a selenium yeast product in combination with chemotherapeutic agents. In particular, selenium yeast product of strain ATCC 74366.
Inventor(s):	Hsia; Houn Simon (Irvine, CA), Yang; Ping (Huntington Beach, CA), Arnold; Michael (Irvine, CA)
Assignee:	Viva America Marketing, Inc. (Costa Mesa, CA)
Application Number:	09/801,124
Patent Claims:	1. A composition comprising: a chemotherapeutic agent, and a composition for oral administration containing dried selenium yeast of the strain ATCC 74366 having an LD.sub.50 greater than 7 mg/kg measured in a Rat Acute Oral Toxicity Model and an intracellular selenium concentration of between greater than 2000 ppm and 5000 ppm. 2. The composition of claim 1, wherein the chemotherapeutic agent is selected from the group consisting of Adriamycin, Doxil, Mitoxantrone, Mitomycin C, Actinomycin, Cytoxan, Bleomycin, BCNA (Carmustine), Velban, Vincristine, Epotoside, Prednisone, Xeloda, S-Fluorouracil, Camptosar, Carboplatin, Cis-Platin, Taxol, Taxatere, Herceptin, Methotrexate, Hydroxyurea, Cytosar, Gemcytabine, Nitrogen Mustard, Procarbazine, Imidazove Carboxamide (Dacarbaziin), Tamoxifen, Estracyte, Jupron, Flutamide, Daunarubicin, Lomostine, Ifusfamide, Mesna, Streptozocin, Interferon, Dexamethasone, Melphalan, Leulovorin, Chlorambucil, Fludarabine, Busulfan, Interleurine-2, Navelbine, Gmerocapto-Purina, and Megestroc. 3. The composition of claim 1, wherein the chemotherapeutic agent is taxol or adriamycin. 4. The composition of claim 1, wherein the dried selenium yeast is combined with a carrier for oral administration as a solid. 5. The composition of claim 4, wherein the carrier is selected from the group consisting of starches, sugars, diluents, granulating agents, lubricating agents, binders and disintegrating agents.

Details for Patent 6,576,233

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2016-09-25
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2016-09-25