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Last Updated: April 20, 2024

Claims for Patent: 6,552,246

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Summary for Patent: 6,552,246

Title:	Transgenic mice comprising CD45 knockout
Abstract:	A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.
Inventor(s):	Mak; Tak Wah (Toronto, CA), Penninger; Josef Martin (Toronto, CA)
Assignee:	University Health Network (Toronto, CA)
Application Number:	08/451,318
Patent Claims:	1. A mutant mouse wherein its endogenous CD45 gene has been disrupted using a DNA construct comprising exons 6-8 of the CD45 gene, wherein a marker sequence has been substituted for at least intron 6 and exon 6, and wherein disruption prevents expression of CD45 on B-cells and T-cells and results in a decreased cytotoxic T-cell response. 2. The mutant mouse of claim 1 wherein the marker sequence is the neo DNA sequence. 3. The mouse of claim 1 that further contains a transgene, wherein the transgene comprises a nucleotide sequence encoding the CD45RO isoform. 4. The mutant mouse of claim 3 wherein the marker sequence is the neo DNA sequence.

Details for Patent 6,552,246

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2020-04-22
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2020-04-22
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2020-04-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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