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Last Updated: March 29, 2024

Claims for Patent: 6,524,580


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Summary for Patent: 6,524,580
Title: Method for treating thyroid disorders
Abstract:A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates the thyroid, thereby reducing a stimulatory effect upon thyroid hormone secretion. Methods for treating calcium metabolism disorders by local administration of a neurotoxin to modulate calcitonin secretion are also disclosed.
Inventor(s): Donovan; Stephen (Capistrano Beach, CA)
Assignee: Allergan Sales, Inc. (Irvine, CA)
Application Number:09/504,538
Patent Claims:1. A method for treating a thyroid disorder, the method comprising the step of injecting the thyroid of a patient, or injecting a sympathetic ganglion which innervates the thyroid, with a therapeutically effective amount of a botulinum toxin to a patient, thereby influencing a secretion of a thyroid hormone, and treating a thyroid disorder.

2. The method of claim 1, wherein the thyroid is injected and the thyroid disorder treated is hypothyroidism.

3. The method of claim 1, wherein a sympathetic ganglion which innervates the thyroid is injected and the thyroid disorder treated is hyperthyroidism.

4. The method of claim 1, wherein the botulinum toxin is administered in an amount of between 10.sup.-3 units per kg of patient weight and 35 units per kg of patient weight.

5. The method of claim 1, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C.sub.1, D, E, F and G.

6. The method of claim 1, wherein the botulinum toxin is botulinum toxin type A.

7. A method for treating hypothyroidism, the method comprising the step of injecting a thyroid with of a therapeutically effective amount of a botulinum toxin, thereby increasing a deficient thyroid hormone secretion from a thyroid cell and treating hypothyroidism.

8. The method of claim 7, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C.sub.1, D, E, F and G.

9. A method for treating hyperthyroidism, the method comprising the step of injecting a sympathetic ganglion which innervates a thyroid cell of a with therapeutically effective amount of a botulinum toxin, thereby reducing an excessive thyroid hormone secretion from the thyroid cell and treating hyperthyroidism.

10. The method of claim 9, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C.sub.1, D, E, F and G.

11. A method for treating hypercalcemia, the method comprising the step of direct administration to a thyroid C cell of a therapeutically effective amount of a botulinum toxin, thereby increasing a deficient calcitonin secretion from a thyroid C cell and treating hypercalcemia.

12. The method of claim 11, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C.sub.1, D, E, F and G.

13. A method for treating hypocalcemia, the method comprising the step of injecting a sympathetic ganglion which innervates a thyroid C cell with a therapeutically effective amount of a botulinum toxin, thereby decreasing an excessive calcitonin secretion from the thyroid C cell and treating hypocalcemia.

14. The method of claim 13, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C.sub.1, D, E, F and G.

15. The method of claim 1, wherein the botulinum toxin is botulinum toxin type A.

16. A method for treating a thyroid disorder, the method comprising the step of injecting a thyroid or a sympathetic ganglion which innervates a thyroid with of a therapeutically effective amount of a botulinum toxin type A, thereby influencing a secretion of a thyroid hormone, and treating a thyroid disorder.

17. A method for treating a thyroid disorder, the method comprising the step of injecting a thyroid or a sympathetic ganglion which innervates a thyroid with a therapeutically effective amount of a botulinum toxin type B, thereby influencing a secretion of a thyroid hormone, and treating a thyroid disorder.

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