Claims for Patent: 6,495,517

Summary for Patent: 6,495,517

Title:	Cyclooxygenase inhibitor
Abstract:	A cyclooxygenase-2-inhibitor containing as an active ingredient a compound having cyclooxygenase-2-inhibitory activity and exhibiting low toxicity that causes only minor side effects. The active compound is represented by the following formula (1) or (1\'): ##STR1## wherein R.sup.1 represents a hydrogen atom or a C1-C3 alkyl group; R.sup.2 represents a hydrogen atom, a hydroxyl group, an organic group capable of being bound through its thiol group within the molecule, or R.sup.1 and R.sup.2 may join to each other to form a single bond; R.sup.3 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxyl group, a trifluoromethyl group, or a nitro group; each of R.sup.4 and R.sup.5, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a C1-C4 alkoxyl group, a trifluoromethyl group, or R.sup.4 and R.sup.5 may join to each other to form a methylenedioxy group.
Inventor(s):	Tanaka; Zyunji (Tokyo, JP)
Assignee:	A. Natterman & Cie. GmbH (Koln, DE)
Application Number:	09/838,125
Patent Claims:	1. A method of inhibiting cyclooxygenase-2 in a host, which comprises administering to a host in need thereof an effective amount of a compound having the formula (1) or (1'): ##STR4## wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; R.sup.2 is a hydrogen atom, a hydroxyl group, an organothiol group that is bound to the selenium atom by its sulfur atom, or R.sup.1 and R.sup.2 are joined to each other by a single bond; R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group having 1-3 carbon atoms, an alkoxyl group having 1-3 carbon atoms, a trifluoromethyl group, or a nitro group; R.sup.4 and R.sup.5 are identical to or different from each other, and each is a hydrogen atom, a halogen atom, an alkoxyl group having 1-4 carbon atoms, a trifluoromethyl group, or R.sup.4 and R.sup.5 are joined to each other to form a methylenedioxy group, a salt thereof, or a hydrate thereof. 2. A method as claimed in claim 1, wherein R.sup.2 is an organothiol group, wherein the organothiol group is a sulfur-containing peptide, protein, or glycoprotein, the sulfur atom of which is bound to the selenium atom. 3. A method as claimed in claim 1, wherein R.sup.2 is an organothiol group, wherein the organothiol group is a sulfur-containing albumin, glutathione group, or .alpha.-amino acid group, the sulfur atom of which is bound to the selenium atom. 4. A method as claimed in claim 3, wherein the albumin is human albumin. 5. A method as claimed in claim 1, which comprises administering 2-phenyl-1,2-benzisoselenazol-3(2H)-one, a salt thereof, or a hydrate thereof. 6. A method as claimed in claim 1, which comprises administering S-(2-phenylcarbamoyl-phenylselenyl)-albumin, a salt thereof, or a hydrate thereof.

Details for Patent 6,495,517

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942		2018-07-01
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954		2018-07-01
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976		2018-07-01
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978		2018-07-01