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Last Updated: April 18, 2024

Claims for Patent: 6,437,099

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Summary for Patent: 6,437,099

Title:	Fluorescene--activating antisera and IgG fraction therefrom
Abstract:	An antiserum containing an antibody, which when combined with an immunogen having a nonfluorescent dye, confers fluorescent ability to the dye. In particular, an antiserum which confers fluorescent ability on a conjugate of an immunogenic substance and Malachite Green.
Inventor(s):	Jibu; Masaki (Hamamatsu, JP)
Assignee:	Hamamatsu Photonics K.K. (Shizuoka-Ken, JP)
Application Number:	09/003,710
Patent Claims:	1. An antiserum comprising an antibody directed against an antigen formed by conjugation of an immunogenic substance with Malachite Green; wherein the Malachite Green is nonfluorescent when said antibody and said Malachite Green are in non complexed form, and is fluorescent upon complexation of said antibody with said Malachite Green. 2. The antiserum according to claim 1, wherein the immunogenic substance is at least one member selected from the group consisting of bovine serum albumin, human serum albumin, egg albumin, bovine .gamma. globulin, equine serum globulin, human .gamma. globulin, ovine .gamma. globulin, bovine thyroglobulin, porcine thyroglobulin and hemocyanin. 3. An IgG fraction of an antiserum comprising an antibody directed against an antigen formed by conjugation of an immunogenic substance with Malachite Green; wherein the Malachite Green is nonfluorescent when said antibody and said Malachite Green are in non-complexed form, and is fluorescent upon complexation of said antibody with said Malachite Green. 4. The IgG fraction according to claim 3, wherein the immunogenic substance is at least one member selected from the group consisting of bovine serum albumin, human serum albumin, egg albumin, bovine .gamma. globulin, equine serum globulin, human .gamma. globulin, ovine .gamma. globulin, bovine thyroglobulin, procine thyroglobulin and hemocyanin. 5. A composition comprising an antibody directed against an antigen formed by conjugation of an immunogenic substance with Malachite Green; wherein the Malachite Green is nonfluorescent when said antibody and said Malachite Green are in non-complexed form and is fluorescent upon complexation of said antibody with said Malachite Green. 6. The composition according to claim 5, wherein the immunogenic substance is selected from the group consisting of bovine serum albumin, human serum albumin, egg albumin, bovine .gamma. globulin, equine serum globulin, human .gamma. globulin, ovine .gamma. globulin, bovine thyroglobulin, porcine thyroglobulin and hemocyanin.

Details for Patent 6,437,099

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2040-01-28
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2040-01-28
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2040-01-28
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2040-01-28
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2040-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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