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Last Updated: April 25, 2024

Claims for Patent: 6,432,701

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Summary for Patent: 6,432,701

Title:	Derived tyrosine hydroxylase gene expression system
Abstract:	The invention discloses a new system for gene expression. The system is based in particular on the use of derived sequences of the first intron of the tyrosine hydroxylase gene having transcription enhancing properties. The system is particularly useful in the production of proteins in vitro, ex vivo or in vivo, particularly in gene therapy applications.
Inventor(s):	Mallet; Jacques (Paris, FR), Meloni; Rolando (Paris, FR), Ravassard; Philippe (Paris, FR), Treilhou; Fabienne (Gif sur Yvette, FR)
Assignee:	Aventis Pharma S.A. (Antony, FR)
Application Number:	09/171,162
Patent Claims:	1. An expression cassette comprising a transcriptional promoter, a coding sequence, and a transcriptional enhancer consisting of a DNA fragment having the nucleotide sequence (TCAT).sub.n -(CAT).sub.o -(TCAT).sub.p, where n is between 1 and 50, o is between 0 and 20, and p is between 0 and 50. 2. The expression cassette of claim 1, wherein the transcriptional promoter is functional in mammalian cells. 3. The expression cassette of claim 2, wherein the transcriptional promoter is a viral, ubiquitous or tissue-specific promoter. 4. The expression cassette of claim 2, wherein the transcriptional promoter comprises a TATA or INR region. 5. The expression cassette of claim 1, wherein the transcriptional enhancer is in the sense orientation. 6. The expression cassette of claim 1, wherein the transcriptional enhancer is in the antisense orientation. 7. An expression vector comprising an expression cassette according to claim 1. 8. The expression vector of claim 7, which is a plasmid vector. 9. The expression vector of claim 7, which is a viral vector. 10. An expression cassette comprising a transcriptional promoter, a coding sequence, and a transcriptional enhancer consisting of a DNA fragment having the nucleotide sequence of the first intron of a tyrosine hydroxylase gene. 11. The expression cassette of claim 10, wherein the transcriptional promoter is functional in mammalian cells. 12. The expression cassette of claim 11, wherein the transcriptional promoter is a viral, ubiquitous or tissue-specific promoter. 13. The expression cassette of claim 11, wherein the transcriptional promoter comprises a TATA or INR region. 14. The expression cassette of claim 10, wherein the transcriptional enhancer is in the sense orientation. 15. The expression cassette of claim 10, wherein the transcriptional enhancer is in the antisense orientation. 16. An expression vector comprising an expression cassette of claim 10. 17. The expression vector of claim 16, which is a plasmid vector. 18. The expression vector of claim 16, which is a viral vector. 19. An expression cassette comprising a transcriptional promoter, a coding sequence, and a transcriptional enhancer consisting of a DNA fragment having a nucleotide sequence of an allele of the microsatellite HUMTH01 sequence. 20. The expression cassette of claim 19, wherein the transcriptional promoter is functional in mammalian cells. 21. The expression cassette of claim 20, wherein the transcriptional promoter is a viral, ubiquitous or tissue-specific promoter. 22. The expression cassette of claim 20, wherein the transcriptional promoter comprises a TATA or INR region. 23. The expression cassette of claim 19, wherein the transcriptional enhancer is in the sense orientation. 24. The expression cassette of claim 19, wherein the transcriptional enhancer is in the antisense orientation. 25. An expression vector comprising an expression cassette of claim 19. 26. The expression vector of claim 25, which is a plasmid vector. 27. The expression vector of claim 25, which is a viral vector.

Details for Patent 6,432,701

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2016-04-25
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2016-04-25
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2016-04-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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