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Last Updated: March 29, 2024

Claims for Patent: 6,421,613


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Summary for Patent: 6,421,613
Title: Data processing of the maize prolifera genetic sequence
Abstract:The invention provides isolated prolifera nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering prolifera levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.
Inventor(s): Nadimpalli; Ramgopal (Bloomfield, NJ), Simmons; Carl R. (Des Moines, IA)
Assignee: Pioneer Hi-Bred International, Inc. (Des Moines, IA)
Application Number:09/604,605
Patent Claims:1. A data processing system having a memory and enabling programs to process data contained in said memory, comprising: at least one data structure in said memory, said data structure supporting computer program access to data representing a genetic sequence, wherein said genetic sequence is: (i) a polynucleotide of at least 1500 contiguous nucleotides in length with at least 85% sequence identity to a polynucleotide sequence of SEQ ID NO: 1, or (ii) a polypeptide of at least 550 contiguous amino acids in length with at least 85% sequence identity to a polypeptide sequence of SEQ ID NO: 2, wherein sequence identity is determined by the GAP program under default parameters; and at least one genetic identification, analysis, or modeling computer program in said memory, said computer program directing the execution of instructions by said data processing system and using said genetic sequence to identify, analyze, or model at least one data element corresponding to a logical subcomponent of said genetic sequence.

2. The data processing system of claim 1, wherein said logical sub-component of said genetic sequence is a member selected from the group consisting of restriction enzyme sites, endopeptidase sites, major grooves, minor grooves, beta-sheet, alpha helices, ORFs, 5'UTRs, 3'UTRs, ribosome binding sites, glycosylation sites, signal peptide domains, intron-exon junctions, poly-A signals, transcription initiation sites, translation start sites, translation termination sites, methylation sites, zinc finger domains, modified amino acid sites, preproprotein-proprotein junctions, proprotein-protein junctions, transit peptide domains, SNPs, SSRs, RFLPs, insertion elements, transmembrane spanning regions and stem-loop structures.

3. A computer implemented process for identifying, analyzing, or modeling a genetic sequence, comprising: providing a computer memory with data representing at least one genetic sequence, wherein said genetic sequence comprises: (i) a polynucleotide of at least 1500 contiguous nucleotides in length with at least 85% sequence identity to a polynucleotide sequence of SEQ ID NO: 1, or (ii) a polypeptide of at least 550 contiguous amino acids in length with at least 85% sequence identity to a polypeptide sequence of SEQ ID NO: 2, wherein sequence identity is determined by the GAP program under default parameters; providing a computer program to identify, analyze or model at least one logical sub-component reflecting the higher order organization of said genetic sequence; executing said computer program while granting said computer program access to said data representing said genetic sequence; and outputting results of said process.

4. The process of claim 3, further comprising isolating a nucleic acid comprising said genetic sequence from a nucleic acid library.

5. The process of claim 4, wherein said nucleic acid library is a full-length enriched cDNA library.

6. A data processing system, comprising: data representing at least one genetic sequence in a memory of said data processing system, wherein said genetic sequence is: (i) a polynucleotide of at least 1500 contiguous nucleotides in length with at least 85% sequence identity to a polynucleotide sequence of SEQ ID NO: 1, or (ii) a polypeptide of at least 550 contiguous amino acids in length with at least 85% sequence identity to a polypeptide sequence of SEQ ID NO: 2, wherein sequence identity is determined by the GAP program under default parameters; a genetic identification, analysis, or modeling computer program designed to govern the processing of said data; and, a data processor having an output for storing or displaying data processing results, said data processor containing said data and said computer program and executing instructions according to said computer program to process said data or a contiguous subsequence thereof.

7. The data processing system of claim 6, wherein said data processing system is a distributed system having its input and output portions separated from at least some of its processing portions.

8. The data processing system of claim 7, wherein said data processing is distributed over an intranet, an internet, or both.

9. The data processing system of claim 6, wherein said program comprises at least one of: a sequence similarity application, a protein structure application, a sequence alignment application, a translation application, a O-glycosylation prediction application, or a signal peptide prediction application.

10. The data processing system of claim 6, wherein said data processor stores said data in a memory while processing said data, and wherein successive portions of said data are copied sequentially into at least one register of said data processor where said portions are processed.

11. A memory for storing data that can be accessed by a computer programmed to implement a process for effecting the identification, analyses, or modeling of a sequence of a polynucleotide, said memory comprising data representing a polynucleotide of at least 1500 contiguous nucleotides in length with 85% sequence identity to the sequence of SEQ ID NO: 1, wherein sequence identity is determined by the GAP program under default parameters.

12. A memory for storing a data structure that can be accessed by a computer programmed to implement a process for effecting the identification, analysis, or modeling of a sequence of a polynucleotide, said memory comprising: data stored within said memory representing a polynucleotide of at least 1500 contiguous nucleotides in length and having at least 85% sequence identity to the sequence of SEQ ID NO: 1, wherein said sequence identity is determined by the GAP program under default parameters, a data structure associated with said data and reflecting the underlying organization and structure of the data to facilitate computer program access to data elements corresponding to logical sub-components of the sequence, said data structure stored within said memory; and, said data structure enabling said polynucleotide to be identified and manipulated by said computer program.

13. A process for effecting the identification, analysis, or modeling of a polynucleotide sequence or its derived peptide sequence through use of a computer having a memory, said process comprising: placing into said memory data representing a polynucleotide of at least 1500 contiguous nucleotides in length with 85% sequence identity to the sequence of SEQ ID NO: 1, wherein sequence identity is determined by the GAP program under default parameters, developing within said memory a data structure associated with said data and reflecting the underlying organization and structure of the data to facilitate a computer program access to data elements corresponding to logical sub-components of the sequence, programming said computer with said computer program containing instructions sufficient to implement the process for effecting the identification, analysis, or modeling of said polynucleotide sequence or said peptide sequence, and executing said computer program on said computer while granting said computer program access to said data and to said data structure within said memory.

14. A machine-readable media containing a computer program and data, comprising: a computer program stored on said media containing instructions sufficient to implement a process for effecting the identification, analysis, or modeling of a representation of a polynucleotide or peptide sequence; data stored on said media representing a sequence of a polynucleotide of at least 1500 contiguous nucleotides in length with at least 85% sequence identity to SEQ ID NO: 1, wherein sequence identity is determined by the GAP program under default parameters; and, a data structure reflecting the underlying organization and structure of said data to facilitate said computer program access to data elements corresponding to logical sub-components of the sequence, said data structure being inherent in said program and in the way in which said computer program organizes and accesses said data.

Details for Patent 6,421,613

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2019-07-09
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2019-07-09
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2019-07-09
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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