Claims for Patent: 6,419,921
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Summary for Patent: 6,419,921
Title: | DNA-constructs of blood clotting factors and P-Selectin |
Abstract: | A DNA construct is disclosed which encodes a fusion protein comprising an amino acid sequence of a blood clotting factor like Factor IX and an amino acid sequence of the cytoplasmic domain of P-Selectin. Such construct may be used for the somatic gene therapy of patients suffering from a defiency of a blood coagulation factor. |
Inventor(s): | Negrier; Claude (Irigny, FR), Plantier; Jean Luc (Lyons, FR) |
Assignee: | Aventis Behring GmbH (Marburg, DE) |
Application Number: | 09/440,509 |
Patent Claims: | 1. A DNA construct encoding a fusion protein comprising an amino acid sequence of a blood clotting factor and an amino acid sequence of the cytoplasmic domain of P-Selectin.
2. The DNA construct as claimed in claim 1 comprising an amino acid sequence of the blood clotting factor IX. 3. The DNA construct as claimed in claim 2 wherein the 3'-end of the Factor IX-DNA is fused to the 5' end of the nucleic acid sequence encoding the cytoplasmic domain of intracellular P-selectin. 4. The DNA construct as claimed in claim 2 wherein between the sequence of the Factor IX-DNA and the sequence of the P-Selectin-DNA the two amino acids Thr-Arg are inserted. 5. The DNA construct as claimed in claim 2 further comprising insertion of the first intron (Intron 1) of the human Factor IX gene. 6. The DNA construct as claimed in claim 5 wherein the first intron has been truncated at both Sca 1 sites prior to insertion. 7. A fusion protein expressed by the DNA construct of claim 1. 8. A mammalian cell comprising the DNA construct of claim 1, wherein the DNA construct is expressed. 9. The mammalian cell wherein the DNA construct of claim 1 encodes Factor IX. |
Details for Patent 6,419,921
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2018-12-02 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2018-12-02 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2018-12-02 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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