Claims for Patent: 6,413,738

Summary for Patent: 6,413,738

Title:	House dust mite allergen, Der f VII, and uses therefor
Abstract:	Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.
Inventor(s):	Thomas; Wayne Robert (Nedlands, AU), Chua; Kaw-Yan (Taipei, TW)
Assignee:	ImmuLogic Pharmaceutical Corporation (Waltham, MA)
Application Number:	08/553,336
Patent Claims:	1. An isolated Group VII protein allergen of Dermatophagoides farinae, Der f VII, comprising the amino acid sequence shown in FIGS. 6A and 6B (SEQ ID NO:7) or the mature portion thereof. 2. A composition comprising the Der f VII protein allergen of claim 1 and a pharmaceutically acceptable carrier. 3. An isolated Group VII protein allergen of Dermatophagoides farinae, Der f VII, encoded by the nucleic acid shown in FIGS. 6A and 6B (SEQ ID NO: 6). 4. An isolated Group VII protein allergen of Dermatophagoides farinae, Der f VII, encoded by the nucleotide bases 43 through 681 of the nucleic acid shown in FIG. 6A and 6B (SEQ ID NO: 6). 5. A composition comprising the Der f VII protein allergen of either claim 3 or claim 4 and a pharmaceutically acceptable carrier. 6. The isolated peptide of claim 1, produced by chemical synthesis. 7. The isolated peptide of claim 1, produced by recombinant expression. 8. A method of producing an isolated Group VII protein allergen of Dermatophagoides farinae, Der f VII, or the mature portion thereof, the method being selected from the group consisting of: a) recombinantly producing the protein a host cell transformed with a nucleic acid encoding a Der f VII protein allergen comprising the amino acid sequence shown in FIGS. 6A and 6B (SEQ ID NO:7), or the mature portion thereof; and b) chemically synthesizing the protein, wherein the protein comprises the amino acid sequence shown in FIGS. 6A and 6B (SEQ ID No: 7) or the mature protein thereof. 9. The method of claim 8 wherein the nucleic acid comprises the nucleotide sequence shown in FIGS. 6A and 6B (SEQ ID NO: 6).

Details for Patent 6,413,738

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides farinae	Injection	101834	09/15/1958		2013-03-12