Claims for Patent: 6,410,224
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Summary for Patent: 6,410,224
Title: | Ribozyme treatment of diseases or conditions related to levels of NF-.kappa.B |
Abstract: | Enzymatic RNA molecules which cleave rel A mRNA. |
Inventor(s): | Stinchcomb; Dan T. (Boulder, CO), Draper; Kenneth G. (Boulder, CO), McSwiggen; James (Boulder, CO) |
Assignee: | Ribozyme Pharmaceuticals, Inc. (Boulder, CO) |
Application Number: | 08/777,916 |
Patent Claims: | 1. A method for specifically cleaving RNA encoding a Rel-A subunit of NF-k B protein using an enzymatic RNA molecule, comprising the step of contacting said RNA with said
enzymatic RNA molecule under conditions suitable for said cleaving.
2. The method of claim 1, wherein said enzymatic RNA molecule is in a motif selected from the group consisting of Hammerhead, Hairpin, Hepatitis Delta Virus, Group I Intron, RNAse P RNA and VSRNA. 3. A method of claim 1, wherein said enzymatic RNA molecule comprises between 12 and 100 nucleotides complementary to said RNA encoding the Rel-A subunit of the NF-kB protein. 4. A method of claim 1, wherein said enzymatic RNA molecule comprises between 14 and 24 nucleotides complementary to said RNA encoding the Rel-A subunit of the NF-kB protein. |
Details for Patent 6,410,224
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2012-12-07 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2012-12-07 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2012-12-07 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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