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Last Updated: March 29, 2024

Claims for Patent: 6,399,091


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Summary for Patent: 6,399,091
Title: Wound dressing for the controlled release of active substance to wounds, and process for its manufacture
Abstract:A wound dressing for the controlled release of active substance to wounds, especially of wound healing-promoting substances to slow-healing, chronic wounds, is characterized in that said wound dressing has a layered structure for the purpose of absorbing liquid, especially wound exudate, under volume increase, said layered structure at least comprising one polymer-containing layer (1), one woven fabric-like or nonwoven-like layer (2) and at least one active substance, and in that the polymer-containing layer (1) contains hydrocolloid-containing swellable hydrogel as absorbent for liquid.
Inventor(s): Berthold; Achim (Andernach, DE), Muller; Walter (Neuwied, DE), Flother; Frank-Ulrich (Schaffhausen, CH), Naeff; Rainer (Langwiesen, CH)
Assignee: LTS Lohamann Therapie-Systeme AG (Andernach, DE)
Application Number:09/584,876
Patent Claims:1. A wound dressing having a layered structure for the controlled release of active substance to wounds comprising:

two polymer-containing layers each comprising a hydrocolloid-containing swellable hydrogel as an absorbent;

two woven layers; and

at least one active substance in at least one of the layers, the polymer-containing layers and the woven layers being superposed in alternating sequence.

2. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains at least one polyethylene glycol derivative.

3. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains at least one polymer based on vinyl pyrrolidone.

4. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains at least one polymer based on acrylic and/or methacrylic acid.

5. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains at least one polymer based on silicone.

6. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains at least one polymer based on isobutylene, isoprene or styrene.

7. The wound dressing of claim 1 wherein the absorbent is a polymer.

8. The wound dressing of claim 7 wherein the polymer is a cellulose derivative or a polyethylene derivative or a starch derivative.

9. The wound dressing of claim 8 wherein the cellulose derivative is carboxymethyl cellulose.

10. The wound dressing of claim 1 wherein the active substance is a biologically active peptide or protein.

11. The wound dressing of claim 10 wherein the biologically active peptide or protein is a growth factor.

12. The wound dressing of claim 11 wherein the growth factor is Platelet Derived Growth Factor.

13. The wound dressing of claim 11 wherein the growth factor is Becaplermin, Epidermal Growth Factor, Platelet Derived Endothelial Cell Growth Factor, Acidic Fibroblast Growth Factor, Basic Fibroblast Growth Factor, Transforming Growth Factor alpha, Transforming Growth Factor beta, Keratinocyte Growth Factor, Insulin-Like Growth Factor 1 or 2, or Tumor Necrosis Factor.

14. The wound dressing of claim 1 wherein the woven layer is based on polyester, polyurethane or cellulose.

15. The wound dressing of claim 1 wherein a surface thereof which is intended for application possesses adhesive properties.

16. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains 40 to 80 wt. % of polyvinyl pyrrolidone, 15 to 45 wt. % of polyethylene glycol 400, and up to 40 wt. % of sodium carboxymethyl cellulose and the at least one active substance comprises becaplermin.

17. The wound dressing of claim 1 wherein at least one of the polymer-containing layers contains 60 wt. % of polyvinyl pyrrolidone, 35 wt. % of polyethylene glycol 400, and 5 wt. % of sodium carboxymethyl cellulose and the at least one active substance comprises becaplermin.

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