Claims for Patent: 6,395,261

Summary for Patent: 6,395,261

Title:	Walnut seed meal extract
Abstract:	An aqueous extract of walnut seed meal useful in cosmetic and dermatologic compositions is disclosed. The extract is obtained by macerating the pressed seed meal from Juglans sp. in water and concentrating the water.
Inventor(s):	Laforet; Jean-Pierre (Genas, FR)
Assignee:	Gattefosse S.A. (Saint Priest, FR)
Application Number:	09/866,433
Patent Claims:	1. A walnut seed cake extract produced by the process of: (a) bringing walnut seed cake into contact with water, whereby an aqueous solution and a water-insoluble residue are produced; (b) separating the aqueous solution from the residue; and (c) removing at least a portion of water from said aqueous solution. 2. A walnut seed cake extract according to claim 1 produced by the process of: (a) bringing walnut seed cake into contact with four to 99 parts by weight of water at 3.degree. C. to 100.degree. C. for a period of one minute to forty hours, whereby said aqueous solution and said water-insoluble residue are produced. 3. A walnut seed cake extract according to claim 1 produced by the process of: (a) macerating walnut seed cake in about 19 parts by weight of water at 3.degree. C. to 10.degree. C. for about 20 hours to produce said aqueous solution and said residue. 4. A walnut seed cake extract as claimed in claim 1, wherein the removal of water is carried out by reverse osmosis. 5. A walnut seed cake extract as claimed in claim 3 wherein the maceration is carried out at about 4.degree. C. 6. A walnut seed cake extract as claimed in claim 1, wherein removal of water is carried to substantial completion, resulting in a powder. 7. A walnut seed cake extract as claimed in claim 1, wherein the walnut seed cake is derived from the seed of Juglans regia. 8. A method for therapeutic or prophylactic treatment of skin cells comprising applying to said skin cells the walnut seed cake extract of claim 1. 9. A method according to claim 8 for protecting skin cells against oxidative stress induced by UVB radiation comprising applying said walnut seed cake to said skin cells. 10. A method according to claim 8 for inhibiting inflammation in skin cells comprising applying said walnut seed cake to said skin cells. 11. A method according to claim 8 for retarding ageing in skin cells comprising applying said walnut seed cake to said skin cells. 12. A method according to claim 8 for stimulating the synthesis of proteins by cells of the dermis and epidermis comprising applying said walnut seed cake to said cells. 13. A method according to claim 8 for stimulating the synthesis of glycosaminoglycans by cells of the dermis comprising applying said walnut seed cake to said cells. 14. A method according to claim 8 for inhibiting collagenase in skin cells comprising applying said walnut seed cake to said skin cells. 15. A method according to claim 8 for inhibiting elastase in skin cells comprising applying said walnut seed cake to said skin cells. 16. A method according to claim 8 for inhibiting apoptosis in skin cells comprising applying said walnut seed cake to said skin cells. 17. A cosmetic composition comprising the walnut seed cake extract of claim 1 and a pharmaceutically acceptable vehicle for topical administration. 18. The cosmetic composition as claimed in claim 17, wherein said walnut seed extract is in the form of a solution having a concentration of between 10 and 40 g of dry matter per liter of solvent. 19. The cosmetic composition as claimed in claim 18, characterized in that it contains between 0.5 and 10% by weight of said solution. 20. A cosmetic composition comprising (1) from 90 to 99.5% by weight of a pharmaceutically acceptable vehicle for topical administration and (2) from 0.5 to 10% by weight of a walnut seed cake extract produced by the process of: (a) macerating walnut seed cake in water at 3.degree. C. to 10.degree. C. to produce an aqueous solution and a residue; (b) separating the aqueous solution from the residue; and (c) removing at least a portion of water from said aqueous solution to provide a solution having a concentration of between 10 and 40 g of dry matter per liter of solvent. 21. The cosmetic composition as claimed in claim 20, wherein said solution has a concentration of about 30 g of dry matter per liter of solvent and said solution constitutes between 2 and 5% by weight of said composition. 22. A method of cosmetic treatment wherein a therapeutically effective quantity of the cosmetic composition as claimed in claim 17 is applied to the skin. 23. A method of cosmetic treatment wherein a therapeutically effective quantity of the cosmetic composition as claimed in claim 20 is applied to the skin.

Details for Patent 6,395,261

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2018-11-27