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Last Updated: March 29, 2024

Claims for Patent: 6,358,539


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Summary for Patent: 6,358,539
Title: Pharmaceutical compositions for reducing the appearance of cellulite
Abstract:Compositions and methods for reducing or eliminating the appearance of cellulite. The method involves administering to a patient in need of treatment therapeutically effective amounts of a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin, a primary antioxidant component in an amount sufficient to substantially inhibit the formation of collagenase and elastase, at least one amino acid component in an amount sufficient to assist in the thickening of the skin, and at least one transition metal component in an amount effective to bind collagen and elastic fibers and thicken skin so as to reduce or eliminate the appearance of cellulite. A preferred method of treatment further includes administering the components above in conjunction with a vascular dilator to improve blood supply to the skin and/or a fat burner to reduce absorption or digestion of fat in the digestive tract or to prevent the production of fat. The compositions and methods may optionally include chromium picolinate to facilitate entry of sugar into cells to improve fat metabolism. In one embodiment, these methods encompass administering the amounts as a pharmaceutical composition.
Inventor(s): Murad; Howard (Marina del Rey, CA)
Assignee:
Application Number:09/641,376
Patent Claims:1. A pharmaceutical composition for reducing or eliminating the appearance of cellulite in a patient comprising:

a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin;

a primary antioxidant component in an amount sufficient to substantially inhibit the activity of collagenase and elastase;

at least one amino acid component in an amount sufficient to assist in the thickening of the skin;

at least one transition metal component in an amount effective to bind collagen and elastic fibers and thicken the skin;

at least one of either a fat burner to reduce absorption of fat in the digestive tract or prevent the production of fat, or a vascular dilator to improve blood supply to the skin; and

chromium picolinate in an amount sufficient to facilitate entry of sugar into the cells to improve metabolism of fats by the body.

2. The composition of claim 1 wherein a fat burner is present.

3. The composition of claim 1 wherein a vascular dilator is present.

4. The composition of claim 1, wherein the sugar compound is present in an amount of from about 5 to 50 weight percent of the composition, the primary antioxidant component is present in an amount of about 5 to 50 weight percent of the composition, the amino acid component is present in an amount of about 8 to 60 weight percent of the composition, and the transition metal component is present in an amount of about 0.5 to 15 weight percent of the composition.

5. The composition of claim 1, wherein the sugar compound is N-acetylglucosamine, or a pharmaceutically acceptable salt or ester thereof.

6. The composition of claim 5, wherein the N-acetylglucosamine, or a pharmaceutically acceptable salt or ester thereof, is present in an amount of about 5 to 30 weight percent of the composition.

7. The composition of claim 1, wherein the anti-oxidant is a vitamin C source.

8. The composition of claim 7, wherein the vitamin C source is present in an amount of about 5 to 50 weight percent of the composition.

9. The composition of claim 1, wherein the amino acids are selected from lysine, proline, cysteins, glycine, methionine, or mixtures thereof.

10. The composition of claim 9, wherein the amino acids are each present in an amount of about 2 to 25 weight percent of the composition.

11. The composition of claim 1, wherein the transition metal is one or more of zinc, manganese, or copper.

12. The composition of claim 11, wherein the zinc, if present, is present in an amount of about 1 to 10 weight percent of the composition; the manganese, if present, is present in an amount of about 1 to 10 weight percent of the composition; and the copper, if present, is present in an amount of about 0.1 to 5 weight percent of the composition.

13. The composition of claim 1, further comprising a proanthanol or proanthocyanidin.

14. The composition of claim 13, wherein the proanthanol or proanthocyanidin is present in an amount of 0.5 to 5 weight percent of the composition.

15. The composition of claim 3, wherein the vascular dilator is one or more of an extract of ginko biloba, a ginsing extract, or phenylalanine.

16. The composition of claim 2, wherein the fat burner is hydroxy acetic acid or chitin.

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