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Last Updated: April 25, 2024

Claims for Patent: 6,350,867

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Summary for Patent: 6,350,867

Title:	Compositions and methods for enhancing osseous growth, repair and regeneration
Abstract:	Novel human DLX3 genes and their encoded proteins are provided herein. The proteins encoded by the disclosed DLX3 and DLX3.DELTA. genes play a pivotal role in craniofacial growth and development. DLX3 genes and their encoded proteins provide valuable therapeutic targets for the design of proliferative agents which augment bone growth and repair.
Inventor(s):	Hart; Thomas C. (Clemmons, NC), Price; Jennifer A. (Mooresville, NC)
Assignee:	Wake Forest University (Winston-Salem, NC)
Application Number:	09/031,962
Patent Claims:	1. An isolated, human nucleic acid molecule comprising SEQ ID NO: 3, said nucleic acid molecule encoding a DLX3.DELTA. protein, said DLX3.DELTA. protein comprising a homeobox domain. 2. The nucleic acid molecule of claim 1, which is DNA. 3. The DNA molecule of claim 2, which is a cDNA comprising a sequence approximately 2.5 kilobases in length that encodes a truncated human DLX3.DELTA. protein. 4. The DNA molecule of claim 2, which is a gene comprising intron and exons, said gene being located between loci p17S806 and D17S788 on chromosome 17, the exons of said gene comprising the nucleic acid of SEQ ID NO: 3, said gene having a promoter sequence of SEQ ID NO: 5 and said exons encoding said DLX3.DELTA. protein. 5. The isolated nucleic acid molecule of claim 1, further comprising the nucleotide sequence of SEQ ID NO: 5. 6. An isolated nucleic acid molecule consisting of an RNA transcribed from SEQ ID NO: 3, wherein the isolated nucleic acid molecule specifically hybridizes to SEQ ID NO: 3. 7. An isolated nucleic acid molecule comprising a sequence selected from the group consisting of: a) SEQ ID NO: 3; and b) a sequence encoding the polypeptide of SEQ ID NO: 4. 8. An isolated nucleic acid molecule encoding a DLX3.DELTA. protein of SEQ ID NO: 4. 9. An isolated nucleic acid molecule which is the complement of SEQ ID NO:3. 10. An isolated nucleic acid molecule consisting of the nucleotide sequence of SEQ ID NO: 5.

Details for Patent 6,350,867

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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