Claims for Patent: 6,346,255

Summary for Patent: 6,346,255

Title:	Plant polar lipid permeation enhancer in a cosmetic pad for improving skin appearance
Abstract:	Devices for the improvement of skin appearance are provided, said devices including a pad with a backing layer, a release layer, and a vehicle located therebetween, the vehicle containing a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. The invention also relates to a method of improving skin appearance using the devices of the invention.
Inventor(s):	Fotinos; Spiros (Athens, GR)
Assignee:	Lavipharm Laboratories Inc. (East Windsor, NJ)
Application Number:	09/232,422
Patent Claims:	1. A device for the improvement of skin appearance, comprising: a pad having a backing layer, a release layer, and a vehicle located therebetween, the vehicle comprising a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. 2. A device according to claim 1, wherein the plant polar lipid comprises a ceramide preparation containing at least one of a ceramide or glycoceramide. 3. The device according to claim 1, wherein the cosmetic formulation comprises a cosmetic active agent and at least one of an antimicrobial agent, an antioxidant, a preservative, an anti-irritant, a plasticizer and a solubilizer. 4. The device according to claim 2, wherein the cosmetic formulation further comprises a cosmetic active agent and at least one of an anti-microbial agent, an anti-oxidant, a preservative, an anti-irritant, a plasticizer and a solubilizer. 5. The device according to claim 1, wherein the concentration range of the plant polar lipid is 0.1 to 5%w/w. 6. The device according to claim 2, wherein the concentration range of the plant polar lipid is 0.1 to 5%w/w. 7. The device according to claim 3, wherein the concentration range of the cosmetic active agent is 1 to 20% w/w, the microbial agent is 0 to 5% w/w, the antioxidant is 0 to 4% w/w, the preservative is 0 to 5% w/w, the anti-irritant is 0 to 7% w/w, the plasticizer is 0-10% w/w and the solubilizer is 0 to 5% w/w. 8. The device according to claim 3, wherein the cosmetic agent is selected from the group consisting of anti-hyperpigmentation agents, anti-blotching agents, anti-aging agents, eye contour agents, slimming agents, anti-cellulite agents, soothing agents, sunburn agents, anti-irritating agents, skin firming agents, anti-elastase agents, anti-collagenase substances, free radical scavengers, seboregulators, hydratives, and .alpha.-hydroxy acids, vitamins, anti-oxidants and minerals. 9. A method of delivering a cosmetic agent to a topical site for improving skin appearance, comprising: (a) selecting a multilaminate device comprising a backing layer, a vehicle and a release liner; (b) providing the cosmetic agent and an enhancer for dispersion within the vehicle wherein the enhancer is a sphingolipid; and (c) forming a device for improvement of skin appearance. 10. A method according to claim 9, wherein the sphingolipid is a plant polar lipid. 11. A method according to claim 10, wherein the plant polar lipid is a ceramide preparation containing at least one of a glycoceramide or a ceramide. 12. A method according to claim 9, wherein improving skin appearance further includes any of increasing skin elasticity, decreasing wrinkles, removing pimples, reducing cellulitis, increasing skin moisture, regulating sebum secretion and reducing hyperpigmentation and blotching. 13. A composition for enhancing the penetration of agents through the outer layer of the skin, comprising: a preparation of plant polar lipid, the plant polar lipid containing at least one of a ceramide and a glycoceramide. 14. A method of improving skin appearance, comprising: (a) removing the release layer on the device of claim 1 to expose the vehicle; and, (b) contacting the vehicle to skin. 15. The method of claim 14 wherein improving skin appearance comprises increasing skin moisture. 16. The method of claim 14 wherein improving skin appearance comprises regulating sebum secretion. 17. The method of claim 14, wherein improving skin appearance comprises reducing hyperpigmentation or blotching. 18. The method of claim 14, wherein improving skin appearance comprises increasing skin elasticity. 19. The method of claim 14, wherein improving skin appearance comprises decreasing wrinkles. 20. The method of claim 14, wherein improving skin appearance comprises reduction in cellulitis.

Details for Patent 6,346,255

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2018-01-15