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Last Updated: April 24, 2024

Claims for Patent: 6,342,477

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Summary for Patent: 6,342,477

Title:	Remedies for thrombocytopenia
Abstract:	Agents for preventing and treating thrombocytopenia, thrombocytopenic purpura and various diseases that tend to cause bleeding due, presumably, to thrombocytopenia contain a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.
Inventor(s):	Tamura; Masahiko (Shizuoka-ken, JP), Oda; Yasuhiro (Nagano-ken, JP)
Assignee:	Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:	09/117,379
Patent Claims:	1. A method for treating thrombocytopenia in a patient in need thereof, comprising administering to said patient an effective amount of a composition comprising parathyroid hormone (PTH) or a derivative thereof for a time and under conditions to ameliorate said thrombocytopenia. 2. The method according to claim 1, wherein human PTH (1-84) is administered. 3. The method according to claim 1, wherein human PTH (1-34) is administered. 4. The method according to claim 1 wherein said effective amount is in the range of 1 .mu.g to 1,000 .mu.g per kg of body weight administered systematically at a frequency ranging from once per day to once per month. 5. The method according to claim 1 wherein said effective amount is from 5 .mu.g to 200 .mu.g per kg of body weight administered from once every two weeks to once daily. 6. The method according to claim 1 wherein the route of said administration is subcutaneously. 7. The method according to claim 1 wherein the route of said administration is intravenously. 8. The method according to claim 1 wherein the route of said administration is intranasally. 9. The method according to claim 1 wherein the route of said administration is transpulmonarily. 10. The method of claim 1 wherein said PTH or PTH derivative is selected from the group consisting of human PTH (1-34), human PTH (1-64), human PTH (35-84), bovine PTH (1-34), human PTH (1-84), human PTH (1-38) and human PTH (1-37). 11. The method according to claim 1 wherein said PTH or PTH derivative modified with polyethylene glycol and administered. 12. The method according to claim 1 wherein said PTH or PTH derivative is administered encapsulated within microcapsules. 13. The method according to claim 1, wherein said PTH or PTH derivative is incorporated in a sheet of gel.

Details for Patent 6,342,477

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2016-02-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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