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Last Updated: April 23, 2024

Claims for Patent: 6,335,388

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Summary for Patent: 6,335,388

Title:	Prolamine-plant polar lipid composition, its method of preparation and applications thereof
Abstract:	Prolamine-plant polar lipid compositions are provided, said compositions including a mixture of a prolamine, a plant polar lipid, at least one polyalcohol in a hydro-alcoholic solution, and an active agent, wherein the composition forms a substantially homogeneous dispersion with skin adhesive properties; wherein the dispersion forms a film and wherein the film contains a gradient of concentrations of the active agent.
Inventor(s):	Fotinos; Spiros (Athens, GR)
Assignee:	Lavipharm Laboratories Inc. (East Windsor, NJ)
Application Number:	09/165,846
Patent Claims:	1. A composition, comprising: a mixture of a prolamine, a plant polar lipid, at least one polyalcohol in a hydro-alcoholic solution, and an active agent, wherein the composition forms a substantially homogeneous dispersion with skin adhesive properties; wherein the dispersion forms a film and wherein the film contains a gradient of concentrations of the active agent. 2. A composition according to claim 1, wherein the prolamine is a cereal prolamine. 3. A composition according to claim 2, wherein the cereal prolamine is gliadin. 4. A composition according to claim 1, wherein the plant polar lipid is isolated from a cereal. 5. A composition according to claim 1, wherein the hydro-alcoholic solution is hydro-ethanol. 6. A composition according to claim 4, wherein the plant polar lipid is a preparation that includes a ceramide or a glycosylceramide at a concentration greater than 50%. 7. A composition according to claim 1, wherein the prolamine has a w/w in the range of 20-40%, the plant polar lipids have a w/w in the range 0.1%-5%. 8. A composition according to claim 1, further comprising a plasticizing agent. 9. A composition according to claim 8, wherein the polyalcohol comprises a concentration of glycerol or a concentration of sorbitol. 10. A composition according to claim 9, wherein the concentration of polyalcohol is in the range of 2.5%-80% dry weight. 11. A composition according to claim 1, wherein the active agent is a therapeutic agent. 12. A composition according to claim 1, wherein the active agent is a cosmetic agent. 13. A composition according to claim 1, wherein the film is rolled into a compact form. 14. A composition according to claim 1, wherein the dispersion is in a form suited for adhering at a site selected from oral, buccal, rectal, vaginal and topical sites. 15. A composition according to claim 8, wherein the film forms a protective barrier for underlying tissue, on a wound surface. 16. A composition according to claim 15, wherein the protective barrier retains a therapeutic agent for promoting wound healing. 17. A composition according to claim 1, wherein the dispersion has hemostatic properties. 18. A composition according to claim 15, wherein the wound is a burn. 19. A composition according to claim 11, wherein the active agent is selected from the group comprising: local and systemic pain relievers, anti-arthritis agents; buccally active agents, agents for enhancing dental hygiene, agents for enhancing mouth hygiene, antimicrobials agents, anesthetic agents, keratolytic agent; wound healing agents; antipyretics; anti-inflammatory agents, antispasmodic agents, sympathomimetic drugs, antiparasitic agents, hypoglycemic drugs, nutritional agents, cardiovascular agents, agents for smoking cessation, vitamins, hemostatic agents, skin growth agents. 20. A composition according to claim 12, wherein the active agent is selected from the group comprising: agents for improving skin appearance, topically active agents for treating dermal and nail diseases; anti-hyperpigmentation, anti-blotching, anti-aging, eye contour, slimming, anti-cellulite, soothing/sunburn anti-irritating, skin firming and lifting, anti-elastase and anti-collagenase agents, free radical scavengers, seboregulators, hydratives, and AHA (.alpha.-hydroxy acids) specific products. 21. A composition according to claim 1, further comprising an oxidizing agent contained within the dispersion. 22. A composition according to claim 21, wherein the oxidizing agent is vitamin E.

Details for Patent 6,335,388

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2017-10-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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