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Last Updated: March 28, 2024

Claims for Patent: 6,303,588


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Summary for Patent: 6,303,588
Title: Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor
Abstract:Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically effective amount of a biocomplex comprising at least one bioactive agent from each of the three informational blocks of biological information transfer, each agent being present in an amount sufficient to correct the biological information transfer of the patient under treatment and resulting in the resumption of normal cell metabolism, said amount being less than the buffering amount of said agent; together with a carrier therefor.
Inventor(s): Danielov; Michael M. (Rego Park, NY)
Assignee: Danielov; Michael M. (Rego Park, NY)
Application Number:09/228,384
Patent Claims:1. A method for treating the skin of a patient with abnormal skin cell metabolism to correct the abnormal skin cell metabolism and promote the resumption of normal skin cell metabolism comprising applying to the portions of the skin of such patient which have abnormal skin cell metabolism a composition containing a bioactive agent and a biologically acceptable carrier therefor, the amount of the bioactive agent being sufficient to correct the abnormal skin cell metabolism but less than the buffering amount of said agent, wherein the composition comprises:

adenosine-5-triphosphate;

guanosine-5-triphosphate;

phosphoinositedes containing:

1) 15-20% phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-monophosphate;

2) the remainder is a mixture of phosphatidylinositol and phosphatidylserine;

Type I brain exract containing 10-20% phosphatidylinosides, 50-60% phosphatidylserines;

adenosine 3'5'-cyclic monophosphate sodium salt;

guanosine 3'5'-cyclic monophosphate;

d-myo-Inositol triphosphate; and

calmodulin.

2. The method of claim 1 wherein the composition comprises by weight per 1 kg of formulated product:

1-50 mg adenosine-5-tiphosphate;

1-30 mg guanosine-5-triphosphate;

10-100 .mu.g phosphoinositedes containg:

1) 15-20% phosphotidyl inositol 4,5-diphosphate and phosphatidylinositol 4-monophosphate;

2) the remainder is a mixture of phosphatidylinositol and phosphotidylserine;

0.5-10 mg Type 1 brain extract containing 10-20% phosphatidyhinosilides, 50-60% phosphatidylserines;

1-10 mg adenosine 3'5'-cyclic monophosphate sodium salt;

0.1-5 mg guanosine 3'5'-cyclic monophosphate;

1-66 .mu.g d-myo-Inositol triphosphate; and

1-20 .mu.g calmodulin.

3. The method of claim 1 wherein the composition also comprises at least one component selected from the group consisting of adrenocorticotropic hormone; .beta.-lipotropin; .beta.-endotphin; somatotropin; follicle-stimulatirng hormone; luteinizing hormone; thyrotropic hormone; vasopressin; patathyroid hormone; thyrocalcitonin; angiotensin II; glucagon; vasoactive intestinal peptide; gastric inhibitory polypeptide; and insulin.

4. The method of claim 3 wherein the components listed in claim 3, when present in the composition, comprise by weight per 1 kg of formulated product:

2-120 ng adrenocorticotropic hormone;

1-10 .mu..beta.-lipotropin .beta.-endorphin;

1-10 .mu.g somatotropin;

0.01-1.0 .mu.g follicle-stimulating hormone;

0.05-0.5 .mu.g luteinizing hormone;

0.05-0.15 .mu.g thyrotropic hormone;

0.02-1.0 .mu.g vasopressin;

0.5-2.0 parathyroid hormone;

20-120 ng vasoactive intestinal peptide; and

0.5-5 .mu.g insulin.

5. The method of claim 1 wherein the composition also comprises at least one component selected from the group consisting of hydrocortisone; corticosterone-21-sulfate; progesterone; .beta.-estradiol; estriol-3-sulfate sodium salt; cholecalciferol sulfate; epinephrine hydrochloride; arterenol hydrochloride; and aldosterone.

6. The method of claim 5 wherein the components listed in claim 5, when present in the composition, comprise by weight per 1 kg of formulated product:

25-250 .mu.g hydrocortisone;

1-30 .mu.g corticosterone-21-sulfate;

2-10 .mu.g progesterone;

50-500 ng .beta.-estradiol;

200-700 ng estriol-3-sulfate sodium salt;

200-700 ng epinephrine hydrochloride;

300-900 ng arterenol hydrochloride; and

10-600 ng .alpha.-aldosterone-21-hemisuccinate.

7. The method of claim 1 wherein the composition also comprises at least one component selected from the group consisting of prostaglandin D.sub.2, prostaglandin E.sub.1, prostaglandin E.sub.2, prostaglandin F.sub.2.alpha. and prostaglndin I.sub.2.

8. The method according to claim 7 wherein the components listed in claim 7, when present in the composition, comprise by weight per 1 kg of formulated product:

1-5 .mu.g prostaglandin D.sub.2,

1-5 .mu.g prostaglandin E.sub.1,

1-5 .mu.g prostaglandin E.sub.2,

0.5-3 .mu.g prostaglandin F.sub.2.alpha., and

1-5 .mu.g prostaglandin I.sub.2.

9. A method for treating the skin of a patient with abnomial skin cell metabolism to correct the abnormal skin cell metabolism and promote the resumption of normal skin cell metabolism comprising applying to the portions of the skin of such patient which have abnormal skin cell metabolism a composition containing a bioactive agent and a biologically acceptable carrier therefor, the amount of the bioactive agent being sufficient to correct the abnormal skin cell metabolism but less than the buffering amount of said agent, wherein the composition comprises:

adenosine-5-triphosphate;

guanosine-5-triphosphate;

phosphoinositedes containing:

1) 15-20% phosphotidyl inositol 4,5-diphosphate and phosphatidylinositol 4-monophosphate;

2) the remainder is a mixture of phosphotidylinositol and phosphotidylserine;

Type I brain extract containing 10-20% phosphotidylinosilides, 50-60% phosphatidylserines, and other brain lipids;

adenosine 3'5'-cyclic monophosphate sodium salt;

guanosine 3'5'-cyclic monophosphate;

d-myo-Inositol triphosphate;

protein kinase;

coenzyme A;

.beta.-nicotinamide adenine dinucleotide;

.beta.-nicotinamide adenine dinucleotide phosphate; and

calmodulin;

wherein the composition further comprises a protein-peptide biocomplexbioactive agent selected from the group comprising somatotropin; follicle-stimulating hormone; luteinizig hormone; vasopressin; thyrocalcitonin; angiotensin; glucagon; vasoactive intestinal peptide; gastric inhibitory polypeptide; and mixtures thereof;

wherein the composition further comprises a second bioactive agent selected from the group comprising hydrocortisone; corticosterone-21-sulfate; progesterone; .beta.-estradiol; estriol-3-sulfate sodium salt; epinephrine hydrochloride; arterenol hydrochloride; aldosterone and mixtures thereof; and

wherein the composition further comprises a third bioactive agent selected from the group comprising prostaglandin D.sub.2, prostaglandin E.sub.1, prostaglandin E.sub.2, prostaglandin F.sub.2.alpha. prostaglandin I.sub.2, and mixtures thereof.

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