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Last Updated: March 28, 2024

Claims for Patent: 6,280,951


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Summary for Patent: 6,280,951
Title: Method for prediction of PTH reactivity by polymorphism of PTHR gene
Abstract:A method for predicting reactivity to parathyroid hormone by determining the genotype with respect to polymorphism in the parathyroid hormone receptor gene. The results obtained by the analysis of genetic polymophism are useful for predicting the tendency for a hemodialyzed patient to develop severe secondary hyperparathyroidism, or for predicting the tendency for a human individual to develop severe primary hyperparathyroidism. Also, this method is useful for predicting the therapeutic effects by predicting reactivity to parathyroid hormone in a patient who is being treated for regressive osteoporosis by administration of parathyroid hormone.
Inventor(s): Heishi; Masayuki (Sagamihara, JP), Ishida; Osamu (Sagamihara, JP), Tazawa; Hiromitsu (Sagamihara, JP), Tsukamoto; Yusuke (Kanagawa, JP)
Assignee: Tsukamoto; Yusuke (Yokohama, JP) Sumikin Bio-Science, Inc. (Sagamihara, JP)
Application Number:09/521,656
Patent Claims:1. A method for predicting reactivity to parathyroid hormone in a human, comprising determining a genotype in the parathyroid hormone receptor gene with respect to Van91 I polymorphism, thereby predicting the reactivity to parathyroid hormone, wherein detection of the VV or Vv genotype in the parathyroid hormone receptor gene with respect to the Van91 I polymorphism indicates an increase in PTH reactivity relative to the vv genotype.

2. The method according to claim 1, wherein the genotype is determined by amplifying the first intron region of the parathyroid hormone receptor gene and treating the amplified DNA fragment with restriction enzyme Van91 I to obtain the digestion pattern.

3. The method according to claim 2, wherein the amplification is carried out using a primer having the sequence of SEQ ID NO:1 and a primer having the sequence of SEQ ID NO:2.

4. A primer set for use in analyzing the Van91 I polymorphism in the parathyroid hormone receptor gene, consisting of a primer having the sequence of SEQ ID NO:1 and a primer having the sequence of SEQ ID NO:2.

5. A kit for use in predicting reactivity to parathyroid hormone in a human, comprising the primer set according to claim 4 and restriction enzyme Van91I.

6. A method for predicting reactivity to parathyroid hormone in a patient who is being treated for regressive osteoporosis by administration of parathyroid horme, comprising determining a genotype in the parathyroid hormone receptor gene with respect to Van91 I polymorphism, thereby predicting the reactivity to parathyroid hormone.

7. The method according to claim 6, wherein the genotype is determined by amplifying the first intron region of the parathyroid hormone receptor gene and treating the amplified DNA fragment with restriction enzyme Van91 I to obtain the digestion pattern.

Details for Patent 6,280,951

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2019-03-09
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2019-03-09
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2019-03-09
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 ⤷  Try a Trial 2019-03-09
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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