Claims for Patent: 6,274,564

Summary for Patent: 6,274,564

Title:	Compositions of cobalamin and related corrinoids, and uses thereof
Abstract:	Novel compositions cobalamin and related corrinoids, and uses thereof, are disclosed. The novel compositions include a corrin, a first amino acid having a side chain which includes a basic or positively charged moiety; and a second amino acid with an uncharged side chain which includes at least one heteroatom. The compositions are useful for, inter alia, treatment of cobalamin deficiency.
Inventor(s):	Sarill; William J. (Arlington, MA), Brennan; Thomas F. (Nyack, NY)
Assignee:
Application Number:	08/936,781
Patent Claims:	1. A composition comprising a mixture in a pharmaceutically acceptable carrier of: (a) cobalamin; (b) a first isolated amino acid selected from the group consisting of lysine and arginine; and (c) a second isolated amino acid selected from the group consisting of glutamine, tyrosine, serine, threonine, and asparagine, in a molar ratio of from about 1:0.1:0.1 to about 1:100:100, wherein (a), (b), and (c) are dissolved in sterile water, and wherein the amounts of (b) and (c) act in concert enhance the cellular uptake of (a) in vivo when compared to the uptake of (a) alone or the uptake of (a) in combination with casein, or (b) alone, or (c) alone. 2. The composition of claim 1 comprising cobalamin, lysine and glutamine in a molar ratio of about 1:2:4. 3. The composition of claim 1 comprising cobalamin, lysine, glutamine and tyrosine in a molar ratio of about 1:2:2:2. 4. The composition of claim 1, wherein the composition further comprises a microorganism capable of catalyzing the formation of a cobalamin:amino acid complex. 5. A method of increasing cellular uptake of cobalamin in the cells of a subject, comprising administering to the subject an active amount of a composition comprising a mixture of: (a) cobalamin; (b) a first isolated amino acid selected from the group consisting of lysine and arginine; and (c) a second isolated amino acid selected from the group consisting of glutamine, tyrosine, serine, threonine, and asparagine, wherein (a), (b), and (c) are dissolved in sterile water, and wherein the amounts of (a), (b), and (c) are combined in a molar ratio of from about 1:.1:0.1, respectively, to about 1:100:100, respectively, such that the amounts of (a), (b), and (c) act in concert to increase the cellular uptake of cobalamin in the cells of the subject when compared to the uptake of cobalamin alone or the uptake of cobalamin in combination with casein, or (b) alone, or (c) alone. 6. The method of claim 5, wherein the composition comprises a pharmaceutically acceptable carrier. 7. A method for treating a condition associated with cobalamin deficiency in a subject, the method comprising: administering to a subject in need thereof a therapeutically effective amount of a composition of claim 1, such that a condition associated with cobalamin deficiency in the subject is treated. 8. The method of claim 7, wherein the subject is a human. 9. The method of claim 8, wherein the condition is Alzheimer's disease. 10. The method of claim 7, wherein the condition is a condition associated with retroviral infection. 11. The method of claim 10, wherein the condition is HIV infection. 12. The method of claim 7, wherein the cellular uptake of cobalamin in the cells of the subject is increased without the use of carrier proteins. 13. The method of claim 12, wherein the subject is a human. 14. The method of claim 12, wherin the condition is characterized by low levels of cobalamin in the nervous system. 15. The method of claim 14, wherein the condition is characterized by low levels of cobalamin in cerebrospinal fluid. 16. The method of claim 14, wherein the condition is peripheral neuropathy. 17. The method of claim 16, wherein the condition is diabetic neuropathy.

Details for Patent 6,274,564

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2016-09-18