Claims for Patent: 6,265,632
✉ Email this page to a colleague
Summary for Patent: 6,265,632
Title: | Animal model for fibroblast growth factor receptor associated chondrodysplasia |
Abstract: | A genetically modified animal is disclosed. The animal has a genetically modified fibroblast growth factor receptor gene integrated in at least one locus in its genome. The genetically modified fibroblast growth factor receptor gene encodes a modified fibroblast growth factor receptor protein, that, when expressed, results in an integral membrane protein having a gain of function. |
Inventor(s): | Yayon; Avner (Moshav Sitria, IL), Segev; Orit (Rehovot, IL) |
Assignee: | Yeda Research and Development Co. Ltd. (Rehovot, IL) Prochon Biotech Ltd. (Rehovot, IL) |
Application Number: | 09/383,630 |
Patent Claims: | 1. A transgenic mouse whose genome comprises a nucleic acid construct, wherein the construct comprises a DNA segment consisting of nt 264-2719 of the sequence disclosed in
SEQ ID NO 2 and said DNA segment comprises the promoter region and 1st exon of the mouse fibroblast growth factor receptor 3 (FGFR3) gene operatively linked to a DNA fragment encoding a mutant of the c form of human FGFR3 wherein the Glycine residue at
position 380 is substituted with Arginine, and wherein said transgenic mouse exhibits the characteristics of human achondroplasia that include, shortening of the limbs, midface hypoplasia, and large skull.
2. The transgenic mouse of claim 1, wherein the transgene is in a hetero- or homo-zygous form. 3. The transgenic mouse of claim 1, wherein the transgenic mouse is a model for human achondroplasia. 4. The transgenic mouse of claim 1, wherein both alleles of the endogenous FGFR3 gene of the transgenic mouse have been inactivated such that said endogenous FGFR3 gene does not produce FGFR3 protein. 5. The transgenic mouse of claim 1, wherein the mouse produces endogenous active FGFR3 protein. 6. A transgenic mouse whose genome comprises a nucleic acid construct, wherein the construct comprises a DNA segment consisting of nt 264-5255 of the sequence disclosed in SEQ ID NO 2 and said DNA segment comprises the promoter region, first exon, first intron, second exon, and 1.66 kb 5' sequences of the mouse FGFR3 gene operatively linked to a DNA fragment encoding a mutant of the murine FGFR3 wherein the Glycine residue at position 374 is substituted with Arginine, and wherein said transgenic mouse exhibits the characteristics of human achondroplasia that include, shortening of the limbs, midface hypoplasia, and large skull. 7. The transgenic mouse of claim 6, wherein the transgene is in a hetero- or homozygous form. 8. The transgenic mouse of claim 6, wherein the transgenic mouse is a model for human achondroplasia. 9. The transgenic mouse of claim 6, wherein the mouse produces endogenous active FGFR3 protein. |
Details for Patent 6,265,632
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2018-08-27 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2018-08-27 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2018-08-27 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.