Claims for Patent: 6,162,165

Summary for Patent: 6,162,165

Title:	Medical radiation treatment device
Abstract:	A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.
Inventor(s):	Apple; Marc G. (Fort Wayne, IN), Bates; Brian L. (Bloomington, IN), DeFord; John A. (Bloomington, IN), Fearnot; Neal E. (West Lafayette, IN)
Assignee:	Cook Incorporated (Bloomington, IN) MED Institute, Inc. (West Lafayette, IN)
Application Number:	09/203,947
Patent Claims:	1. A medical radiation treatment device containing a radioactive fluid to be delivered to a treatment site, comprising: a fluid-tight container having an interior volume in a range from more than 0 to 10 cubic centimeters; and a radioactive fluid in said fluid-tight container having a specific concentration in a range of 150 to 500 millicuries per cubic centimeter, whereby a preferred total activity in a range of 200 to 450 millicuries per administration suitable for effectively treating a patient is ready to be delivered to the treatment site. 2. The radiation treatment device of claim 1, wherein said radioactive fluid includes an inert radioactive gas. 3. The radiation treatment device of claim 1, wherein said radioactive fluid includes a carrier and a radioactive substance dispersed in said carrier. 4. The radiation treatment device of claim 3, wherein said carrier is at least 90% by volume of said radioactive fluid. 5. The radiation treatment device of claim 3, wherein said radioactive substance is at most 10% by volume of said radioactive fluid. 6. The radiation treatment device of claim 3, wherein said carrier is approximately 95% by volume of said radioactive fluid and wherein said radioactive substance is approximately no greater than 5% by total injected volume of said radioactive fluid. 7. The radiation treatment device of claim 3, wherein said radioactive substance includes an inert radioactive gas. 8. The radiation treatment device of claim 7, wherein said radioactive gas includes from a group consisting of xenon, krypton, neon, radon, and isotopes thereof. 9. The radiation treatment device of claim 7, wherein said radioactive gas includes xenon-127 or xenon-133. 10. The radiation treatment device of claim 3, wherein carrier includes sterile water, saline, carbon dioxide gas, or any non-radioactive inert or noble gas. 11. The radiation treatment device of claim 1, wherein said interior volume is in a range of 1 to 7 cubic centimeters. 12. The radiation treatment device of claim 1, wherein said interior volume is in a range of 2 to 6 cubic centimeters. 13. The radiation treatment device of claim 1, wherein said interior volume is in a range of 2 to 3 cubic centimeters. 14. The radiation treatment device of claim 1, wherein said fluid-tight (gas-tight) container includes a plunger base disposed in said interior volume for direct injection. 15. A sealed source of a radioactive fluid comprising: a fluid-tight container having an interior volume in a range of 2 to 6 cubic centimeters; and a radioactive fluid in said fluid-tight container having a specific concentration in a range of 150 to 225 millicuries per cubic centimeter, suitable for effectively treating a patient. 16. The sealed source of claim 15, wherein said radioactive fluid includes a carrier and a radioactive substance dispersed in said carrier. 17. The sealed source of claim 16, wherein said carrier comprises a carbon dioxide gas at least 90% by volume of said radioactive fluid and wherein said radioactive substance comprises a xenon gas having at most 10% by volume of said radioactive fluid. 18. The sealed source of claim 17, wherein said carbon dioxide gas is approximately 95% by volume of said radioactive fluid and wherein said xenon gas is xenon-133 and is approximately 5% by volume of said radioactive fluid. 19. A sealed source of radioactive gas comprising: a gas-tight container having an interior volume of approximately 3 cubic centimeters; and approximately 2 cubic centimeters of a radioactive gas including carbon dioxide gas of approximately 95% by volume of said radioactive gas and xenon-133 gas of approximately 5% by volume of said radioactive gas and having a specific concentration in a range of 150 to 225 millicuries per cubic centimeter, suitable for effectively treating a patient.

Details for Patent 6,162,165

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2017-12-05