Claims for Patent: 6,121,312

Summary for Patent: 6,121,312

Title:	Cyclic ether vitamin D3 compounds and uses thereof
Abstract:	Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic ether structure. Also disclosed are 1.alpha.(OH) 3-epi vitamin D3 compounds, which are produced via the epimerization of a 3-.beta.-hydroxyl group of 1.alpha.(OH) vitamin D3 precursor in vivo. The vitamin D3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D3 compounds.
Inventor(s):	Reddy; Satayanarayana G. (Barrington, RI)
Assignee:	Woman and Infants Hospital (Providence, RI)
Application Number:	09/410,223
Patent Claims:	1. An isolated cyclic ether vitamin D3 compound having the formula (I) as follows: ##STR8## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 2. A method of treating a disorder characterized by an aberrant activity of a vitamin D.sub.3 -responsive cell, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D.sub.3 compound having the formula I as follows: ##STR9## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group, such that the aberrant activity of the vitamin D.sub.3 -responsive cell is reduced. 3. The method of claim 2, wherein the subject is a mammal. 4. The method of claim 3, wherein the mammal is a human. 5. The method of claim 2, wherein the disorder comprises an aberrant activity of an endocrine cell. 6. The method of claim 5, wherein the endocrine cell is a parathryoid cell and the aberrant activity is processing and/or secretion of parathyroid hormone. 7. A method of treating a disorder characterized by an aberrant activity of a hyperproliferative skin cell, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR10## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group, such that the aberrant activity of the hyperproliferative skin cell is reduced. 8. A method of treating secondary hyperparathyroidism, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR11## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 9. A method of treating a disorder characterized by an aberrant activity of a bone cell, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR12## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group, such that the aberrant activity of the bone cell is reduced. 10. A method of treating osteoporosis, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR13## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 11. A method of treating osteodystrophy, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR14## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 12. A method of treating senile osteoporosis, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR15## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 13. A method of treating osteomalacia, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR16## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 14. A method of treating rickets, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR17## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 15. A method of treating osteitis fibrosa cystica, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR18## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 16. A method of treating renal osteodystrophy, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR19## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 17. A method of treating cirrhosis, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR20## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 18. A method of treating chronic renal disease, comprising administering to a subject an effective amount of an isolated cyclic ether vitamin D3 compound having formula I as follows: ##STR21## wherein A.sub.1, A.sub.2 and A.sub.3 are a single or a double bond; X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of a hydrogen, a halogen, a haloalkyl, a hydroxy, a hydroxy-protecting group, an alkyl, an alkenyl, an alkynyl, an alkoxy, an aryl group and a heterocyclic group. 19. A pharmaceutical composition comprising a therapeutically effective amount of a cyclic ether vitamin D.sub.3 compound of claim 1 and a pharmaceutically acceptable carrier. 20. The composition of claim 19, which is suitable for topical or oral administration.

Details for Patent 6,121,312

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2017-05-16