Claims for Patent: 6,114,336

Summary for Patent: 6,114,336

Title:	Cosmetic composition containing a neuropeptide Y receptor antagonist
Abstract:	This invention relates to a cosmetic composition containing at least one NPY-antagonist component mixed with an excipient for cosmetic preparations.
Inventor(s):	Blanc-Ferras; Elisabeth (Donneville, FR), Bono Colombie; Fran.cedilla.oise (Toulouse, FR), Breda; Bernard (Bougival, FR), Courregelongue; Jean (Portet sur Garonne, FR), Ducasse; Catherine (Houilles, FR), Mounier; Remy (Aulnay-sur-Mauldre, FR), Raymond; Paul (Saint Vely Du Fesc, FR), Sabadie; Michel (Bernay, FR), Serradeil-Le-Gal; Claudine (Escaldens, FR), Pol; Vilain (Saussan, FR), Pereillo; Jean-Marie (Portet sur Garonne, FR)
Assignee:	Sanofi (Paris, FR)
Application Number:	09/119,031
Patent Claims:	1. A slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient, wherein the neuropeptide Y antagonist is a fermentation product of the strain Streptomyces sp SEBR 2794 as well as productive mutants thereof. 2. A slimming composition according to claim 1 comprising about 0.00001 % to 5% of neuropeptide Y antagonist and about 0.00001 % to 5% of .alpha.2 antagonist. 3. A slimming composition for topical application comprising a neuropeptide Y antagonist and an a2 antagonist in combination with cosmetically acceptable excipient, wherein the a2 antagonist is a fermentation product of the strain Bacillus licheniformis SEBR 2464 as well as productive mutants thereof. 4. A slimming composition according to claim 3 comprising about 0.00001 % to 5% of neuropeptide Y antagonist and about 0,00001%Y to 6% of a2 antagonist. 5. A slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient, wherein the neuropeptide Y antagonist is a fermentation product of the strain Streptomyces sp SEBR 2794 and the a2 antagonist is a fermentation product of the strain Bacillus licheniformis SEBR 2464. 6. A slimming composition according to claim 5 comprising about 0.00001% to 5% of neuropeptide Y antagonist and about 0.00001 % to 15% of .alpha.2 antagonist. 7. A slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient, additionally containing caffeine and extract of Ginkgo biloba. 8. A slimming composition according to claim 7 comprising about 0,00001 % to 5% of neuropeptide Y antagonist and about 0.00001% to 5% of .alpha.2 antagonist. 9. A slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient, additionally containing a collagen synthesis stimulator, a collagenase or elastase inhibitor, or a vasoprotector. 10. A method of achieving a slimming effect, which process comprises topically applying to selected parts of the body a slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient. 11. A method according to claim 10 comprising about 0.00001% to 5% of neuropeptide Y antagonist and about 0.00001% to 5% of .alpha.2 antagonist. 12. A method according to claim mming effect, which process comprises topically applying a slimming composition according to claim 5 to selected parts of the body. 13. A method according to claim 10, wherein the slimming composition is applied to the thighs. 14. A method according to claim 10, wherein the slimming composition is applied to the thighs and the abdomen from the waist to the knees. 15. A method of controlling lipolysis/lipogenesis in the skin which comprises applying to the skin a slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient. 16. A method of attenuating the fatty, "orange peel" appearance of the skin which comprises applying to the skin a A slimming composition for topical application comprising a neuropeptide Y antagonist and an .alpha.2 antagonist in combination with cosmetically acceptable excipient.

Details for Patent 6,114,336

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2016-10-23