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Last Updated: April 25, 2024

Claims for Patent: 6,110,738

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Summary for Patent: 6,110,738

Title:	Human fast-1 gene
Abstract:	hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-.beta. receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-.beta. family. The invention includes tools for investigating the TGF-.beta. signaling pathway and screening for compounds which modulate the action of TGF-.beta..
Inventor(s):	Zhou; Shibin (Cockeysville, MD), Zawel; Leigh (Bowie, MD), Vogelstein; Bert (Baltimore, MD), Kinzler; Kenneth W. (BelAir, MD)
Assignee:	The Johns Hopkins University (Baltimore, MD)
Application Number:	09/113,309
Patent Claims:	1. A subgenomic polynucleotide which encodes the hFAST-1 protein as shown in SEQ ID NO:2. 2. The subgenomic polynucleotide of claim 1 which is intron-free. 3. The subgenomic polynucleotide of claim 1 which comprises the sequence shown in SEQ ID NO:1. 4. A recombinant vector comprising the polynucleotide of claim 1. 5. A recombinant vector comprising the polynucleotide of claim 2. 6. A recombinant vector comprising the polynucleotide of claim 3. 7. A recombinant host cell which comprises the polynucleotide of claim 1. 8. A recombinant host cell which comprises the polynucleotide of claim 2. 9. A recombinant host cell which comprises the polynucleotide of claim 3. 10. The subgenomic polynucleotide of claim 1 which is isolated. 11. The subgenomic polynucleotide of claim 2 which is isolated. 12. The subgenomic polynucleotide of claim 1 which is isolated.

Details for Patent 6,110,738

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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