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Last Updated: April 19, 2024

Claims for Patent: 6,080,877

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Summary for Patent: 6,080,877

Title:	Taxanes
Abstract:	The invention provides taxanes that are conjugates of cis-docosahexaenoic acid and taxotere. The conjugates are useful in treating cancer.
Inventor(s):	Swindell; Charles S. (Merion, PA), Shashoua; Victor E. (Brookline, MA), Bradley; Matthews O. (Laytonsville, MD), Webb; Nigel L. (Bryn Mawr, PA)
Assignee:	Neuromedica, Inc. (Conshohocken, PA)
Application Number:	08/868,476
Patent Claims:	1. A composition of matter comprising a covalent conjugate of cis-docosahexaenoic acid and Taxotere. 2. The composition of matter of claim 1, wherein the composition is: ##STR16## . 3. The composition of matter of claim 1, wherein the composition is: ##STR17## . 4. The composition of matter of claim 1, wherein the composition is: ##STR18## . 5. The composition of matter of claim 1, wherein the composition is: ##STR19## . 6. A pharmaceutical composition comprising a conjugate of cis-docosahexaenoic acid and Taxotere, and a sterile, pharmaceutically acceptable carrier. 7. The pharmaceutical composition of claim 6, wherein the conjugate is: ##STR20## . 8. The pharmaceutical composition of claim 6, wherein the conjugate is: ##STR21## . 9. The pharmaceutical composition of claim 6, wherein the conjugate is: ##STR22## . 10. The pharmaceutical composition of claim 6, wherein the conjugate is: ##STR23## . 11. The pharmaceutical composition of claim 6 further comprising an anti-cancer agent other than the conjugate. 12. The pharmaceutical composition of claim 7 wherein the anti-cancer agent is selected from the group consisting of: Aminoglutethimide; Asparaginase; Bleomycin; L-Buthiamine Sulfoxide; Busulfan; Camptothecin; Carboplatin; Carmustine (BCNU); Chlorambucil; Cisplatin (cis-DDP); Cyclophosphamide; Cytarabine HCI; Dacarbazine; Dactinomycin; Daunorubicin HCI; Doxorubicin HCI; Edatrexate; Estramustine phosphate sodium; Etoposide (V16-213); Floxuridine; Fluorouracil (5-FU); Flutamide; Gallium Nitrite; Hydroxyurea (hydroxycarbamide); Idarubicin; Ifosfamide; Interferon Alfa-2a, Alfa 2b; Leuprolide acetate (LHRH-releasing factor analogue); Lomustine (CCNU); Mechlorethamine HCI (nitrogen mustard); Megestrol; melphalan; Mercaptopurine; Methotrexate (MTX); Mitomycin; Mitotane (o.p'-DDD); Mitoxantrone HCI; Octreotide; Plicamycin; Prednisone; Procarbazine HCI; Streptozocin; Tamoxifen citrate; Taxanes; Taxoids; Thioguanine; Thiotepa; Tiasofuran; Topotecan; Vinblastine sulfate; Vincristine sulfate; Amsacrine (m-AMSA); Azacitidine; Hexamethylmelamine (HMM); Interleukin 2; Mitoguazone (methyl-GAG); Methyl glyoxal bis-guanylhydrazone (MGBG); Pentostatin; Semustine (methyl-CCNU); and Teniposide (VM-26).

Details for Patent 6,080,877

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978	⤷ Try a Trial	2016-05-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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