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Last Updated: April 25, 2024

Claims for Patent: 6,054,125

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Summary for Patent: 6,054,125

Title:	Purified mite allergen
Abstract:	The present invention is directed to novel purified and isolated mite allergens possessing mite allergen activity with a molecular weight of about 94,000, about 40,000, about 16,000 or about 14,000 as determined by SDS-PAGE, which can be isolated from extracts of mites, and to a process for producing such mites allergens. The purified and isolated mite allergens of the present invention are useful as a pharmaceutical and a diagnostic composition for mite allergic diseases.
Inventor(s):	Oka; Satoru (Hiroshima, JP), Ono; Kazuhisa (Hiroshima, JP), Shigeta; Seiko (Hiroshima-ken, JP), Wada; Takeshi (Hiroshima-ken, JP)
Assignee:	Fumakilla Limited (Tokyo, JP) Hiroshima University (Hiroshima-ken, JP)
Application Number:	09/009,835
Patent Claims:	1. A purified and isolated mite allergen substantially free of any other mite proteins characterized by the following physicochemical and biological properties: 1 being contained in extracts of mite; 2 glycoprotein containing about 15% sugar; 3 a molecular weight of about 40,000 as determined by SDS-polyacrylamide gel electrophoresis; and 4 possessing allergen activity. 2. The purified and isolated mite allergen according to claim 1, wherein said mite is Dermatophagoides farinae. 3. The purified and isolated mite allergen according to claim 1, wherein the protein has the following amino acid, neutral sugar and amino sugar composition: nanomoles amino acids, of 6792.9 nanomoles proteins: Asp 613.1; GLU 846.4; Cys 81.7; Ile 273.6; Phe 212.5; Arg 334.7; Thr 361.0; Gly 676.4; Val 511.1; Leu 540.4; His 147.6; Pro 298.0; Ser 483.3; Ala 875.4; Met 10.7; Tyr 93.3; Lys 433.7; nanomoles neutral sugar, of 797.4 nanomoles: Fuc 12.2; Gal 79.4; Ara 28.7; Man 469.4; Xyl 153.3; Glc 54.4; nanomoles amino sugars, of 67.4 nanomoles: HexNAc 67.4. 4. A pharmaceutical composition for the treatment of mite allergic diseases which comprises as the active ingredient a pharmaceutically effective amount of the purified and isolated mite allergen according to claim 1, and at least one pharmaceutically acceptable carrier or diluent. 5. A diagnostic composition for mite allergic diseases which comprises as the active ingredient a diagnostically effective amount of the purified and isolated mite allergen according to claim 1. 6. A method of treatment for mite allergic diseases which comprises an administration of a pharmaceutically effective amount of the purified and isolated mite allergen according to claim 1. 7. The method of treatment for mite allergic diseases according to claim 6, which is a hyposensitization therapy.

Details for Patent 6,054,125

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides farinae	Injection	101834	09/15/1958	⤷ Try a Trial	2011-03-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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