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Last Updated: April 19, 2024

Claims for Patent: 6,051,561

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Summary for Patent: 6,051,561

Title:	Compounds and compositions for delivering active agents
Abstract:	Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Inventor(s):	Leone-Bay; Andrea (Ridgefield, CT), Wang; Eric (Yonkers, NY), Sarubbi; Donald J. (Bronxville, NY), Leipold; Harry (Elmsford, NY)
Assignee:	Emisphere Technologies Inc. (Hawthorne, NY)
Application Number:	08/797,813
Patent Claims:	1. A composition comprising: (A) at least one active agent; and (B) a compound having the following formula ##STR9## or a salt thereof. 2. A composition as defined in claim 1, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, or a combination thereof. 3. A composition as defined in claim 2, wherein said biologically active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid. 4. A composition as defined in claim 2, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, samatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine (DFO), or any combination thereof. 5. A composition as defined in claim 4, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytosin, vasopressin, vancomycin, DFO, parathyroid hormone, and combinations thereof. 6. A composition as defined in claim 2, wherein said biologically active agent comprises parathyroid hormone. 7. A composition as defined in claim 2, wherein said biologically active agent comprises recombinant human growth hormone. 8. A composition as defined in claim 2, wherein said biologically active agent comprises heparin. 9. A composition as defined in claim 2, wherein said biologically active agent comprises low molecular weight heparin. 10. A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in claim 2. 11. A dosage unit form comprising: (A) a composition as defined in claim 1; and (B) (a) an excipient (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof. 12. A composition as defined in claim 11, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, or a combination thereof. 13. A composition as defined in claim 12, wherein said biologically active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid. 14. A composition as defined in claim 12, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, samatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine (DFO), or any combination thereof. 15. A composition as defined in claim 14, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytosin, vasopressin, vancomycin, DFO, parathyroid hormone, and combinations thereof. 16. A composition as defined in claim 11, wherein said biologically active agent comprises parathyroid hormone. 17. A composition as defined in claim 11, wherein said biologically active agent comprises recombinant human growth hormone. 18. A composition as defined in claim 11, wherein said biologically active agent comprises heparin. 19. A composition as defined in claim 11, wherein said biologically active agent comprises low molecular weight heparin. 20. A dosage unit form as defined in claim 11, comprising a tablet, a capsule, or a liquid. 21. A dosage unit form as defined in claim 20, wherein said dosing vehicle is selected from the group consisting of water, 1,2-propane diol, ethanol, or any combination thereof. 22. A compound having the formula ##STR10## or a salt thereof. 23. A method for preparing a composition, said method comprising mixing: (A) at least one active agent; (B) at least one carrier compound as defined in claim 22; and (C) optionally, a dosing vehicle. 24. A composition comprising: (A) at least one active agent; and (B) a poly(amino acid) comprising a compound as defined in claim 22. 25. A composition as defined in claim 24, wherein said poly(amino acid) comprises a polypeptide.

Details for Patent 6,051,561

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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