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Last Updated: November 30, 2021

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Claims for Patent: 6,022,539

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Summary for Patent: 6,022,539
Title: Amelioration of peyronie\'s disease
Abstract:A method of treating an individual suffering from Peyronie\'s disease. Collagenase is injected into a fibrous Peyronie\'s plaque in the penis of the individual suffering from the disease. The penis immediately after injection, is immobilized and maintained immobile for several hours. The collagenase is in a pharmaceutically acceptable carrier in a concentration of about 20,000 to about 40,000 ABC units per ml., and the amount and concentration of the collagenase is effective to soften and/or rupture the plaque whereby the erectile deviation caused by the plaque is ameliorated
Inventor(s): Wegman; Thomas L. (North Merrick, NY)
Assignee: Advance Biofactures of Curacao (Curacao, AN)
Application Number:09/325,224
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,022,539
Patent Claims:1. A method of treating an individual suffering from Peyronie's disease which comprises injecting collagenase into a fibrous Peyronie's plaque in the penis of the individual suffering from the disease, immobilizing the penis immediately after injection, and maintaining the penis immobile for several hours, the collagenase being in a pharmaceutically acceptable carrier in a concentration of about 20,000 to about 40,000 ABC units per ml., and the amount and concentration of the collagenase being effective to soften and/or rupture the plaque whereby the erectile deviation caused by the plaque is ameliorated.

2. A method according to claim 1 wherein a total amount of at least about 20,000 ABC units of collagenase are applied in one or more injections.

3. A method according to claim 1 wherein the maximum cumulative total dosage does not exceed about 60,000 ABC units.

4. A method according to claim 1 wherein the period of immobility is from about 4 to about 12 hours.

5. A method according to claim 1 wherein that method is repeated after about 3 months.

6. A method according to claim 1 wherein the collagenase is in an aqueous carrier.

7. A method of treating an individual suffering from Peyronie's disease which comprises injecting into a fibrous Peyronie's plaque in the penis of the individual suffering from the disease a series of at least two injections of at least about 10,000 ABC units each of collagenase at least one day apart to provide a total amount of at least about 20,000 ABC units, the amount and concentration of the collagenase being effective to soften and/or rupture the plaque whereby the penile flexure caused by the plaque is ameliorated.

8. A method according to claim 7 wherein each injection is of about 10,000 to about 20,000 ABC units.

9. A method according to claim 7 wherein the collagenase is supplied in a pharmaceutically acceptable carrier in a concentration of about 20,000 to about 40,000 ABC units per ml.

10. A method according to claim 7 wherein the maximum cumulative dosage does not exceed about 60,000 ABC units.

11. A method according to claim 7 wherein a series of at least 3 injections is made during a period of not over ten days.

12. A method according to claim 7 wherein a series of approximately weekly injections of about 10,000 to about 20,000 ABC units each is made up to a maximum cumulative total dosage not to exceed about 60,000 ABC units.

13. A method according to claim 7 wherein another series of injections is made after 3 months.

14. A method according to claim 7 wherein the collagenase is in an aqueous carrier.

15. A method according to any one of claims 1-6 further comprising after the step of immobilization, then physically rupturing the plaque by manipulation.

16. A method according to any one of claims 7-14 further comprising the step of physically rupturing the plaque by manipulation.

Details for Patent 6,022,539

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Free Forever Trial 2039-03-29
Auxilium Pharmaceuticals, Inc. XIAFLEX collagenase clostridium histolyticum For Injection 125338 2010-02-02 ⤷  Free Forever Trial 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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