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Generated: August 21, 2019

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Claims for Patent: 6,005,020

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Summary for Patent: 6,005,020
Title: Bioresorbable compositions for implantable prostheses
Abstract:Crosslinked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable functional groups per polymer chain. These compositions are able to form hydrogels in aqueous environments when crosslinked. These hydrogels are good sealants for implantable prostheses when in contact with an aqueous environment. In addition, such hydrogels can be used as delivery vehicles for therapeutic agents.
Inventor(s): Loomis; Gary L. (Morristown, NJ)
Assignee: Meadox Medicals, Inc. (Oakland, NJ)
Application Number:09/145,588
Patent Claims:1. A medical device having on at least one surface thereof a bioresorbable coating composition, said composition comprising a hydrogel formed from the crosslinking of a polymer comprising the reaction of (i) a bioresorbable region; (ii) a hydrophilic region; (iii) a plurality of crosslinkable functional groups; and (iv) a crosslinking agent.

2. The medical device of claim 1 formed from an implantable material.

3. The medical device of claim 2, wherein said implantable material is selected from the group consisting of polymeric compositions, non-polymeric compositions and combinations thereof.

4. The medical device of claim 3, wherein said implantable material is further selected from the group of olefinic polymeric compositions consisting of polyethylene, polypropylene, polyvinyl chloride, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyvinyl acetate, polystyrene, poly(ethylene terephthalate), polyurethane, polyurea, silicone rubbers, polyamides, polycarbonates, polyaldehydes, natural rubbers, polyether-ester copolymers, styrene-butadiene copolymers and combinations thereof.

5. The medical device of claim 3, wherein said implantable material is further selected from the group of non-polymeric compositions consisting of ceramics, metals, inorganic glasses, pyrolytic carbon and combinations thereof.

6. The medical device of claim 1, wherein said device is an endoprosthesis.

7. The medical device of claim 6, wherein said endoprosthesis is selected from the group consisting of grafts, stents and graft-stent devices.

8. The medical device of claim 2, selected from the group consisting of catheters, guide wires, trocars and introducer sheaths.

9. The medical device of claim 4, wherein said implantable material is a vascular or endovascular graft.

10. The medical device of claim 9, wherein said vascular or endovascular graft is a knitted, braided or woven textile.

11. The medical device of claim 2, wherein said implantable material is made from an extruded polymer.

12. A process for forming a hydrogel comprising:

a. combining (i) a bioresorbable region; (ii) a hydrophilic region; (iii) a plurality of crosslinkable functional groups per polymer chain; and (iv) a crosslinking agent to form an aqueous emulsion of a water-insoluble copolymer; and

b. activating said crosslinking agent.

13. The process of claim 12, wherein said crosslinkable functional groups are olefinically unsaturated.

14. The process of claim 12, wherein said crosslinking agent is a free radical initiator.

15. The process of claim 12, wherein said crosslinking agent is an azo or a peroxide composition.

16. The process of claim 12, wherein said crosslinking agent is thermally or photochemically activated.

17. A process for forming a medical device coated with a hydrogel comprising:

a. applying said hydrogel to said medical device, said hydrogel formed from an aqueous emulsion comprising a water-insoluble copolymer having (i) a bioresorbable region; (ii) a hydrophilic region; (iii) a plurality of crosslinkable functional groups per polymer chain; and (iv) a crosslinking agent; and

b. activating said crosslinking agent in a humid environment.

18. The process of claim 17, wherein said hydrogel is dehydrated.

19. The process of claim 17, wherein said hydrogel is maintained in a hydrated state.

20. The process of claim 17, further including adding a drug or bio-active agent to said emulsion.

21. The process of claim 20, wherein said drug bio-active agent is thrombo-resistant agents, antibiotic agents, anti-tumor agents, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-inflammatory agents, cell cycle regulating agents, and chemically modified equivalents and combinations thereof their homologs, derivatives, fragments, pharmaceutical salts and combinations thereof.

22. The process of claim 20, wherein said drug or bio-active agent is selected from the group of thrombo-resistant agents consisting of heparin, heparin sulfate, hirudin, hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, urokinase, streptokinase, and chemically modified equivalents and combinations thereof their homologs, analogs, fragments, derivatives and pharmaceutical salts thereof.

23. The process of claim 20, wherein said drug or bio-active agent is selected from the group of antibiotic agents consisting of penicillins, cephalosporins, vancomycins, aminoglycosides, quinolones, polymyxins, erythromycins, tetracyclines, chloramphenicols, clindamycins, lincomycins, sulfonamides, and chemically modified equivalents and combinations thereof their homologs, analogs, fragments, derivatives, pharmaceutical salts and mixtures thereof.

24. The process of claim 20, wherein said drug or bio-active agent is selected from the group of anti-tumor agents consisting of paclitaxel, mechlorethamine, chlorambucil, cyclophosphamide, melphalan and ifosfamide, methotrexate, 6-mercaptopurine, 5-fluorouracil, cytarabine, vinblastine, vincristine, etoposide, doxorubicin, daunomycin, bleomycin, mitomycin, carmustine, lomustine, cisplatin, interferon, asparaginase, tamoxifen, flutamide, and chemically modified equivalents and combinations thereof their homologs, analogs, fragments, derivatives, pharmaceutical salts and mixtures thereof.

25. The process of claim 20, wherein said drug or bio-active agent is selected from the group of anti-viral agents consisting of amantadines, rimantadines, ribavirins, idoxuridines, vidarabines, trifluridines, acyclovirs, ganciclovirs, zidovudines, foscarnets, interferons, and chemically modified equivalents and combinations thereof their homologs, analogs, fragments, derivatives, pharmaceutical salts and mixtures thereof .

Details for Patent 6,005,020

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Try a Free Trial Meadox Medicals, Inc. (Oakland, NJ) 2017-08-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 6,005,020

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9908718 Feb 25, 1999
World Intellectual Property Organization (WIPO) 9908718 May 20, 1999
United States of America 2002035168 Mar 21, 2002
United States of America 2003162861 Aug 28, 2003
United States of America 2004082682 Apr 29, 2004
United States of America 2005038134 Feb 17, 2005
United States of America 2007015844 Jan 18, 2007
>Country >Patent Number >Publication Date

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