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Last Updated: April 25, 2024

Claims for Patent: 5,994,094

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Summary for Patent: 5,994,094

Title:	Growth/differentiation factor of the TGF-.beta. family
Abstract:	The invention concerns a protein of the TGF-.beta. family, the DNA coding therefor and a pharmaceutical composition containing the protein.
Inventor(s):	Hotten; Gertrud (Bammental, DE), Neidhardt; Helge (Marburg, DE), Paulista; Michael (Leimen, DE)
Assignee:	Biopharm Gesellschaft Zur Biotechnologischen (Heidelberg, DE)
Application Number:	08/288,508
Patent Claims:	1. An isolated DNA molecule which codes for a protein of the TGF-.beta. family, wherein said DNA molecule comprises a sequence selected from the group consisting of: a) the sequence shown in SEQ ID NO:1, b) a part of SEQ ID NO:1 which encodes the mature protein, c) a nucleotide sequence which encodes the amino acid sequence according to SEQ ID NO:2, d) a nucleotide sequence which encodes a portion of the amino acid sequence according to SEQ ID NO:2, wherein said portion is the mature protein, and e) a part of SEQ ID NO:1 which encodes the amino acid sequence according to SEQ ID NO:13. 2. The DNA molecule according to claim 1, wherein said DNA molecule is the part of SEQ ID NO:1 which encodes the mature protein and further comprises nucleotide sequences coding for functional signal and/or propeptide sequences from a protein of the TGF-.beta. family. 3. The DNA molecule according to claim 2, wherein said functional signal and/or propeptide sequences of said DNA molecule are the functional signal and/or propeptide sequences of SEQ ID NO:2. 4. The DNA molecule according to claim 3, further comprising a non-coding intron between nucleotides 1270 and 1271 of SEQ ID NO:1. 5. The DNA molecule according to claim 1, wherein said DNA molecule comprises nucleotides 640-2142 of SEQ ID NO:1. 6. A vector comprising at least one copy of a DNA molecule according to claim 1. 7. A host cell transformed by a vector according to claim 6. 8. The host cell according to claim 7, wherein said host cell is selected from the group consisting of a bacterium, a fungal cell, a plant cell, and an animal cell. 9. A process for the production of a protein of the TGF-.beta. family, comprising the steps of: culturing a host cell according to claim 7 in a culture media, and isolating TGF-.beta. protein from said host cell or from said culture media. 10. An isolated DNA molecule comprising nucleotide sequences coding for the functional signal and/or propeptide sequence of SEQ ID NO:2.

Details for Patent 5,994,094

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2016-11-30
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2016-11-30
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2016-11-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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