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Last Updated: March 28, 2024

Claims for Patent: 5,989,906


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Summary for Patent: 5,989,906
Title: Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
Abstract:An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene.
Inventor(s): Thompson; James D. (Solon, OH)
Assignee: Ribozyme Pharmaceuticals, Inc. (Cleveland, OH)
Application Number:08/192,942
Patent Claims:1. A catalytic RNA molecule which is active to specifically cleave the sequence shown as any of SEQ. ID. NOS. 1-9.

2. The catalytic RNA molecule of claim 1 wherein said RNA molecule is in a hammerhead motif.

3. The catalytic RNA molecule of claim 1 wherein said RNA molecule is in a hairpin, hepatitis Delta virus, group 1 intron, or RNaseP RNA motif.

4. A mammalian cell comprising a catalytic RNA molecule of any of claims 1, 2 or 3.

5. The cell of claim 4, wherein said cell is a human cell.

6. An expression vector comprising nucleic acid encoding the catalytic RNA molecule of any of claims 1 or 2, in a manner which allows expression of that catalytic RNA molecule within a mammalian cell.

Details for Patent 5,989,906

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2016-11-23
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2016-11-23
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2016-11-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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