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Last Updated: March 29, 2024

Claims for Patent: 5,989,539


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Summary for Patent: 5,989,539
Title: Compounds and compositions for delivering active agents
Abstract:Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopolysaccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
Inventor(s): Leone-Bay; Andrea (Ridgefield, CT), Ho; Koc-Kan (Monmouth Junction, NJ), Sarubbi; Donald J. (Bronxville, NY), Milstein; Sam J. (Larchmont, NY)
Assignee: Emisphere Technologies, Inc. (Tarrytown, NY)
Application Number:08/798,032
Patent Claims:1. A composition comprising:

(A) at least one active agent; and

(B) a compound having the following formula ##STR64## or a salt thereof.

2. A composition as defined in claim 1, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof.

3. A composition as defined in claim 2, wherein said biologically active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid.

4. The composition as defined in claim 3, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine (DFO), and any combination thereof.

5. A composition as defined in claim 3, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytocin, vasopressin, vancomycin, DFO, parathyroid hormone, or combinations thereof.

6. A composition as defined in claim 2, wherein said biologically active agent comprises parathyroid hormone.

7. A composition as defined in claim 2, wherein said biologically active agent comprises recombinant human growth hormone.

8. A composition as defined in claim 2, wherein said biologically active agent comprises interferon.

9. A composition comprising:

(A) at least one active agent; and

(B) a carrier comprising a poly(amino acid) comprising a compound having the following formula ##STR65## or a salt thereof.

10. A composition as defined in claim 9, wherein said carrier comprises a polypeptide.

11. A dosage unit form comprising:

(A) a composition as defined in claim 9; and

(B) (a) an excipient

(b) a diluent,

(c) a disintegrant,

(d) a lubricant,

(e) a plasticizer,

(f) a colorant,

(g) a dosing vehicle, or

(h) any combination thereof.

12. A dosage unit form as defined in claim 11, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof.

13. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid.

14. The dosage unit form as defined in claim 13, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine (DFO), and any combination thereof.

15. A dosage unit form as defined in claim 14, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytocin, vasopressin, vancomycin, DFO, parathyroid hormone, or combinations thereof.

16. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises parathyroid hormone.

17. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises recombinant human growth hormone.

18. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises interferon.

19. A dosage unit form as defined in claim 11, comprising a tablet, a capsule, or a liquid.

20. A dosage unit form as defined in claim 19, wherein said dosing vehicle is selected from the group consisting of water, 1,2-propane diol, ethanol, and any combination thereof.

21. A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in claim 2.

22. A compound having the formula ##STR66## or a salt thereof.

23. A method for preparing a composition, said method comprising mixing:

(A) at least one active agent;

(B) at least one compound as defined in claim 22; and

(C) optionally, a dosing vehicle.

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