Claims for Patent: 5,985,302

Summary for Patent: 5,985,302

Title:	Method for deactivating a contaminant
Abstract:	Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.
Inventor(s):	Dorr; Robert T. (Tucson, AZ), Alberts; David S. (Tucson, AZ)
Assignee:	Supergen, Inc. (San Ramon, CA)
Application Number:	09/113,734
Patent Claims:	1. A method for inactivating HIV infected blood, the method comprising the steps of: (a) swabbing a surface containing the HIV infected blood with a first absorbent, fibrous towlette impregnated with an aqueous solution of a deactivator selected from the group consisting of calcium hypochlorite, sodium hypochlorite and mixtures thereof, to inactivate HIV present in such HIV infected blood; and (b) thereafter swabbing the surface with a second absorbent, fibrous towlette impregnated with an aqueous solution of sodium thiosulfate to neutralize any residual deactivator present on the surface so as to prevent etching of the surface by the residual deactivator. 2. The method of claim 1 wherein the first and second towlettes are made from materials selected from the group consisting of cotton, synthetic blends, and mixtures thereof, the deactivator is sodium hypochlorite, and wherein the ratio of deactivator volume to first towlette weight is in the range of 1.8 to 15 ml/gm, and the ratio of sodium thiosulfate volume to second towlette weight is in the range of 1.8 to 15 ml/gm. 3. A method for inactivating an anticancer drug selected from the group of anticancer drugs consisting of L-asparaginase, carmustine, doxorubicin, daunorubicin, epirubicin, mitoxantrone, mitomycin-C, melphalan, cyclophosphamide, ifosphamide, thio-TEPA, decarbazine, cisplatin, carboplatin, vincristine, vinblastine, vindesine, actinomycin D, bleomycin, etoposide, teniposide, .alpha.-interferon, interleukin 2, tumor necrosis factor, G-CSF, and GM-CSF, the method comprising the steps of: (a) swabbing a surface containing the anticancer drug with a first absorbent, fibrous towlette impregnated with an aqueous solution of a deactivator selected from the group consisting of calcium hypochlorite, sodium hypochlorite and mixtures thereof, to inactivate the anticancer drug; and (b) thereafter swabbing the surface with a second absorbent, fibrous towlette impregnated with an aqueous solution of sodium thiosulfate to neutralize any residual deactivator present on the surface so as to prevent etching of the surface by the residual deactivator. 4. The method of claim 3 wherein the first and second towlettes are made from materials selected from the group consisting of cotton, synthetic blends, and mixtures thereof, the deactivator is sodium hypochlorite, and wherein the ratio of deactivator volume to first towlette weight is in the range of 1.8 to 15 ml/gm, and the ratio of sodium thiosulfate volume to second towlette weight is in the range of 1.8 to 15 ml/gm.

Details for Patent 5,985,302

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2009-04-27