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Last Updated: April 18, 2024

Claims for Patent: 5,959,094

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Summary for Patent: 5,959,094

Title:	p75 TNF receptor promoters
Abstract:	The present invention is an isolated DNA molecule comprising a promoter of the human p75 TNF-R gene having a sequence consisting of a 5\' upstream promoter sequence contained within an approximately 2.0 kbp NcoI fragment of a genomic clone of human p75 TNF-R, or an intron promoter sequence located in the first intron between the first and second exons and contained within an approximately 1.9 kbp SmaI fragment of a genomic clone of human p75 TNF-R. A composition comprising the DNA molecule and a carrier is also described.
Inventor(s):	Wallach; David (Rehovot, IL), Kuhnert; Peter (Berne, CH), Ehrhardt; Gotz (Steisslingen, DE), Kemper; Oliver (Bockenheim, DE)
Assignee:	Yeda Research and Development Co. Ltd. (Rehovot, IL)
Application Number:	08/737,371
Patent Claims:	1. An isolated and purified DNA molecule, comprising a promoter of the human p75 TNF-R gene having a sequence which is selected from the group consisting of a 5' upstream promoter sequence, contained within an approximately 2.0 Kbp NcoI fragment of a genomic clone of human p75 TNF-R, said fragment being located 5' upstream of the first exon and having a sequence comprising at least the sequence extending between nucleotides 1335 and 1527 of SEQ ID NO:1, and an intron promoter sequence located in the first intron between the first and second exons and contained within an approximately 1.9 Kbp SmaI fragment of a genomic clone of human p75 TNF-R, wherein said intron promoter sequence comprises at least the sequence extending between nucleotides 1569 and 1768 of SEQ ID NO:3. 2. The DNA molecule according to claim 1, wherein said intron promoter sequence comprises at least the sequence extending between nucleotides 1569 and 1827 of SEQ ID NO:3. 3. An isolated and purified DNA molecule containing a transcription inhibitory region that is located within the sequence of a 1.9 Kbp SmaI fragment of a genomic clone of human p75 TNF-R and upstream of an intron promoter sequence located in the first intron between the first and second exons, wherein said transcription inhibitory region has a sequence comprising the sequence extending between nucleotides 1 and 1569 of SEQ ID NO:3. 4. A composition, comprising the DNA molecule according to claim 3 and a carrier.

Details for Patent 5,959,094

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2014-05-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2014-05-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2014-05-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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