Claims for Patent: 5,929,099

Summary for Patent: 5,929,099

Title:	Pharmaceutical composition for inhibiting the growth of cancers
Abstract:	A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide in combination with chemotherapeutic agents is disclosed. The particular fungicide used is a benzimidazole derivative. Potentiators can also be included in the composition.
Inventor(s):	Camden; James Berger (West Chester, OH)
Assignee:	Procter & Gamble Co. (Cincinnati, OH)
Application Number:	08/680,470
Patent Claims:	1. A method of treating cancer susceptible to treatment in warm blooded mammals comprising administering a safe and effective amount of a pharmaceutical composition comprising a safe and enhanced amount of a benzimodale selected from the group consisting of: ##STR5## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen, CONHR.sub.3 wherein R.sub.3 is alkyl of less in 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 4thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is an aliphatic hydrocarbon of less than 7 carbon atoms and the pharmaceutically acceptable organic or inorganic acid addition salts thereof, a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator. 2. A method according to claim 1 wherein said chemotherapeutic agent is selected from the group consisting of DNA-interactive Agents, Antimetabolites, Tubulin-Interactive Agents, Hormonal agents, Asparaginase or hydroxyurea. 3. A unit dosage composition for treating cancer susceptible to treatment in animals or humans comprising a safe and enhanced amount of a benzimidazole selected from the group consisting of ##STR6## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen, CONHR.sub.3 wherein R.sub.3 is alkyl of less than 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 4-thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is aliphatic hydrocarbon of less than 7 carbon atoms and pharmaceutically acceptable salts thereof, a safe and effective amount of a chemotherapeutic agent and safe and effective amount of a potentiator. 4. A pharmaceutical composition for treating cancers, tumors or leukemia susceptible to treatment comprising a pharmaceutical carrier and a safe and enhanced amount of a benzimidazole selected from the group consisting of: ##STR7## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen CONHR.sub.3 wherein R.sub.3 is alkyl of less than 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 44thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is aliphatic hydrocarbon of less than 7 carbon atoms, and the pharmaceutically acceptable inorganic or acid addition salts thereof; a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator. 5. A pharmaceutical composition for treating cancer susceptible to treatment in animals or humans comprising a safe and enhanced amount of a benzimidazole selected from the group consisting of: ##STR8## wherein X is hydrogen; Y is hydrogen and R is hydrogen and R.sub.2 is NHCOOR.sub.1 wherein R.sub.1 is an aliphatic hydrocarbon of less than 7 carbon atoms and the pharmaceutically acceptable organic or inorganic acid addition salts thereof; and a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator.

Details for Patent 5,929,099

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2039-02-26