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Last Updated: March 29, 2024

Claims for Patent: 5,928,898


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Summary for Patent: 5,928,898
Title: Multiple drug resistance gene atrD of Aspergillus nidulans
Abstract:The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.
Inventor(s): Skatrud; Paul Luther (Greenwood, IN), de Waard; Maarten A. (Wageningen, NL), Andrade; Alan C. (Wageningen, NL), Peery; Robert Brown (Brownsburg, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/996,545
Patent Claims:1. A DNA compound that comprises an isolated DNA sequence that lacks an intron and encodes SEQ ID NO:2.

2. The DNA compound of claim 1 which comprises the isolated DNA sequence which is SEQ ID NO: 1.

3. A method for constructing a transformed host cell capable of expressing a protein comprising SEQ ID NO:2, said method comprising transforming a host cell with a recombinant DNA vector that comprises an isolated DNA sequence of claim 1.

4. A method for expressing a protein comprising SEQ ID NO:2 in a transformed host cell said method comprising culturing said transformed host cell of claim 3 under conditions suitable for gene expression.

5. A vector comprising an isolated DNA sequence of claim 1.

6. A vector comprising an isolated DNA sequence of claim 2.

7. A host cell containing the vector of claim 5.

8. A host cell containing the vector of claim 6.

Details for Patent 5,928,898

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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