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Last Updated: November 29, 2021

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Claims for Patent: 5,908,824

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Summary for Patent: 5,908,824
Title: Nasally administrable compositions containing physiologically active peptides
Abstract:A nasally administrable composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The composition contains an effective amount of physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a mucosa protecting and/or tissue repairing agent, e.g., gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, cetraxate or troxipide.
Inventor(s): Yanagawa; Akira (Yokohama, JP)
Assignee: Dott Research Laboratory (Yokohama, JP)
Application Number:08/733,065
Patent Claims:1. A nasally administrable composition containing a physiologically active peptide, wherein an effective amount of the physiologically active peptide is dispersed homogeneously in and adsorbed homogeneously onto one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected from the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, and troxipide.

2. A nasally administrable composition according to claim 1 wherein the physiologically active peptide is a peptide hormone, a physiologically active protein, an enzymatic protein, or an opioid peptide.

3. A nasally administrable composition according to claim 1 wherein the physiologically active peptide is calcitonin, insulin, parathyroid hormone, human growth hormone, gonadotropin-releasing hormone or a derivative thereof.

4. A nasally administrable composition wherein calcitonin is dispersed homogeneously in and adsorbed homogeneously onto one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected from the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, and troxipide.

5. A nasally administrable composition wherein parathyroid hormone is dispersed homogeneously in and adsorbed homogeneously onto one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected from the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, and troxipide.

6. A nasally administrable composition wherein gonadotropin-releasing hormone is dispersed homogeneously in and adsorbed homogeneously onto one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected form the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutanine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, and troxipide.

7. A nasally administrable composition wherein human growth hormone is dispersed homogeneously in and adsorbed homogeneously onto one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected from the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, and troxipide.

8. A method of stabilizing a physiologically active peptide, comprising combining the physiologically active peptide with one or more gastric mucosa protecting or gastric mucosa tissue repairing agents selected from the group consisting of gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, cetraxate and troxipide in the nasally administrable composition according to claim 1.

9. A method of treating a patient with a physiologically active peptide comprising nasally administering to a patient in need thereof, a composition according to claim 1.

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